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Megaloblastic anemia

Summary of Megaloblastic anemia
Megaloblastic anemia results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress through the cell cycle properly, leading to cell growth without division, which presents as macrocytosis. Megaloblastic anemia has a rather slow onset, especially when compared to that of other anemias. The defect in red blood cell DNA synthesis is most often due to a deficiency of vitamin B12 and/or folic acid. 

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Pathology

Hematological system

Anemias
Heme synthesis disorders
Coagulation disorders
Platelet disorders
Mixed platelet and coagulation disorders
Thrombosis syndromes (hypercoagulability)
Lymphomas
Leukemias
Leukemoid reaction
Dysplastic and proliferative disorders
Plasma cell dyscrasias
Hematological system pathology review

Assessments
Megaloblastic anemia

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High Yield Notes
4 pages
Flashcards

Megaloblastic anemia

27 flashcards
Questions

USMLE® Step 1 style questions USMLE

3 questions

USMLE® Step 2 style questions USMLE

4 questions
Preview

A 33-year-old woman comes to the office because of fatigue and malaise for 2 months. She states that in addition she has new-onset experienced tingling in her feet. Laboratory investigations show the patient has a macrocytic, megaloblastic anemia. The attending physician believes the patient may have a folate deficiency, and chooses to treat her with intravenous folate alone. Which of the following is the most likely consequence of this treatment decision?

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