Megaloblastic anemia
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Summary of Megaloblastic anemia
Megaloblastic anemia results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress through the cell cycle properly, leading to cell growth without division, which presents as macrocytosis. Megaloblastic anemia has a rather slow onset, especially when compared to that of other anemias. The defect in red blood cell DNA synthesis is most often due to a deficiency of vitamin B12 and/or folic acid.
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Pathology
Hematological system
Anemias
Iron deficiency anemia
Alpha-thalassemia
Sideroblastic anemia
Anemia of chronic disease
Lead poisoning
Hemolytic disease of the newborn
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Autoimmune hemolytic anemia
Pyruvate kinase deficiency
Paroxysmal nocturnal hemoglobinuria
Sickle cell disease (NORD)
Hereditary spherocytosis
Anemia of chronic disease
Aplastic anemia
Fanconi anemia
Megaloblastic anemia
Folate (Vitamin B9) deficiency
Vitamin B12 deficiency
Fanconi anemia
Diamond-Blackfan anemia
Heme synthesis disorders
Coagulation disorders
Platelet disorders
Mixed platelet and coagulation disorders
Thrombosis syndromes (hypercoagulability)
Lymphomas
Leukemias
Leukemoid reaction
Dysplastic and proliferative disorders
Plasma cell dyscrasias
Hematological system pathology review
Microcytic anemia: Pathology review
Non-hemolytic normocytic anemia: Pathology review
Intrinsic hemolytic normocytic anemia: Pathology review
Extrinsic hemolytic normocytic anemia: Pathology review
Macrocytic anemia: Pathology review
Heme synthesis disorders: Pathology review
Coagulation disorders: Pathology review
Platelet disorders: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Thrombosis syndromes (hypercoagulability): Pathology review
Lymphomas: Pathology review
Leukemias: Pathology review
Plasma cell disorders: Pathology review
Myeloproliferative disorders: Pathology review
AssessmentsMegaloblastic anemia
Megaloblastic anemia
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Megaloblastic anemia
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USMLE® Step 1 style questions USMLE
3 questions
USMLE® Step 2 style questions USMLE
4 questions
Preview
A 33-year-old woman comes to the office because of fatigue and malaise for 2 months. She states that in addition she has new-onset experienced tingling in her feet. Laboratory investigations show the patient has a macrocytic, megaloblastic anemia. The attending physician believes the patient may have a folate deficiency, and chooses to treat her with intravenous folate alone. Which of the following is the most likely consequence of this treatment decision?
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