Reviewed by Rishi Desai, MD, MPH
Membranous glomerulonephritis (MGN) is a slowly progressive renal disease that is the most common cause of nephrotic syndrome among Caucasian adults. MGN is caused by immune complex formation in the glomerulus. The immune complexes are formed by binding of antibodies to antigens in the glomerular basement membrane. Primary MGN may be idiopathic or be due to antibodies to phospholipase A2 receptor. Secondary MGN may be due to autoimmune conditions (e.g., systemic lupus erythematosus), infections (e.g., syphilis, malaria, hepatitis B, hepatitis C), or drugs.