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mesothelioma p. NaN
Mesothelioma is an aggressive cancer that attacks the mesothelium, which is a thin membrane made of epithelial cells that lines all of the body’s organs as well as body spaces like the thoracic cavity and abdominal cavity.
In fact, the late Hollywood actor Steve McQueen is well-known for having developed mesothelioma after years of asbestos exposure while in the military.
The vast majority of mesothelioma cases stem from asbestos exposure.
Asbestos is a mineral that was widely used as construction material in everything from paint to insulation to roofing tiles because it has strong fibers that were resistant to fire and served as good insulation.
Asbestos fibers are jagged in shape, and extremely tiny - about 500 times finer than a human hair.
If those tiny asbestos fibers get inhaled over time, they make their way into the interstitial space of the lungs and then slowly make their way over to the epithelial cells of the visceral or parietal pleura - both of which are layers of mesothelium.
The microscopic, jagged asbestos fibers are so small that they can get tangled up with the cell’s chromosomes.
At that point, they can damage the DNA causing a variety of mutations, which ultimately allow those epithelial cells to divide uncontrollably, turning into a tumor.
Interestingly, these growths start to express a lot of calretinin, a calcium-binding protein, involved in regulating calcium levels within the cell - this is something that helps to distinguish mesotheliomas from other types of tumors.
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