Mixed connective tissue disease

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Summary of Mixed connective tissue disease

Mixed connective tissue disease is an autoimmune disease in which the body's defense system attacks itself. Mixed connective tissue disease combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis and is thus considered an overlap syndrome. Distinguishing laboratory characteristics are a positive, speckled antinuclear antibody and an anti-U1 ribonucleoprotein antibody.

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Mixed connective tissue disease

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Mixed connective tissue disease

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ribonucleoprotein antibodies are highly associated with mixed connective tissue disease.

Questions

USMLE® Step 1 style questions USMLE

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A 34-year-old woman comes to the office because of a purplish rash on her face that is most prominent above her eyes. She reports that a few years ago, her fingers become painful and blue when she went outside without gloves. She has also had pain in her elbows and knees, but uses ibuprofen to alleviate symptoms. She denies muscle weakness, difficultly swallowing, palpitations or fever. Her lung examination is notable for a rubbing sound, but the rest of her exam is within normal limits. Which of the following antibodies is most likely present causing her symptoms?

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