Monoclonal antibodies

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Monoclonal antibodies


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bevacizumab and p. 449

Bevacizumab p. 120, 450

Colorectal cancer p. 397

bevacizumab for p. 450


bevacizumab p. 450

Renal cell carcinomas p. 623

bevacizumab for p. 449


With monoclonal antibodies, antibodies means that they target a specific antigen on the cell surface with an antibody-antigen binding; and monoclonal means that each antibody is produced from a specific B cell line consisting of identical B cells.

Okay, now monoclonal antibodies are used for the treatment of cancer and various autoimmune diseases like multiple sclerosis and rheumatoid arthritis.

In this video, we are focusing on the monoclonal antibodies that are used for cancer.

Normally, all of our cells grow and divide through a tightly regulated cell cycle once they receive growth factor signals.

During the cell cycle, if a cell appears abnormal in any way to the immune cells that do constant surveillance, the cell has to fix the problem or undergo apoptosis, or programmed cell death - a bit like cellular suicide, rather than proceed to the next phase of the cell cycle.

But cells can become mutated due to environmental or genetic factors.

A mutated cell becomes cancerous when it starts to divide uncontrollably.

As cancer cells start piling up on each other, they form a small tumor mass and they need to induce blood vessel growth, called angiogenesis, to supply themselves with enough energy.

Some tumors produce vascular endothelial growth factor, or VEGF, which binds to VEGF receptors found on vascular endothelial cells and stimulates angiogenesis.

Also, many tumors overexpress growth factor receptors like the epidermal growth factor receptor, or EGFR, and the human epidermal receptor 2, or HER2, that stimulate cell proliferation and tumor growth.

Malignant tumors are ones that are able to break through the basement membrane.

Some of these malignant tumors go a step further and detach from their basement membrane at the primary tumor site, enter nearby blood vessels or the lymphatic system, and establish secondary sites of tumor growth throughout the body—a process called metastasis.

Now, the monoclonal antibodies that are used for the treatment of cancer target specific antigens that are usually overexpressed on the surface of cancer cells.


Monoclonal antibodies (mAbs) are laboratory-produced proteins that are designed to recognize and bind to specific molecules or cells in the body. They are produced by cloning a single type of immune cell and using the cells to produce large amounts of a specific antibody. Monoclonal antibodies have a variety of medical uses including treatment of cancers, autoimmune, and infectious diseases.


  1. "Katzung & Trevor's Pharmacology Examination and Board Review,12th Edition" McGraw-Hill Education / Medical (2018)
  2. "Rang and Dale's Pharmacology" Elsevier (2019)
  3. "Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition" McGraw-Hill Education / Medical (2017)
  4. "Overview of hemostasis" J.C. Aster, H. Bunn (Eds.), Pathophysiology of Blood Disorders, 2e. McGraw-Hill. (2016)
  5. "Clinical development of targeted and immune based anti-cancer therapies" Journal of Experimental & Clinical Cancer Research (2019)
  6. "Exploring the Immunological Mechanisms Underlying the Anti-vascular Endothelial Growth Factor Activity in Tumors" Frontiers in Immunology (2019)
  7. "Clinical development of targeted and immune based anti-cancer therapies" Journal of Experimental & Clinical Cancer Research (2019)

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