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Renal tubular acidosis
Minimal change disease
Focal segmental glomerulosclerosis (NORD)
Rapidly progressive glomerulonephritis
IgA nephropathy (NORD)
Acute tubular necrosis
Renal papillary necrosis
Renal cortical necrosis
Chronic kidney disease
Polycystic kidney disease
Multicystic dysplastic kidney
Medullary cystic kidney disease
Medullary sponge kidney
Renal artery stenosis
Renal cell carcinoma
Nephroblastoma (Wilms tumor)
Posterior urethral valves
Hypospadias and epispadias
Lower urinary tract infection
Transitional cell carcinoma
Non-urothelial bladder cancers
Congenital renal disorders: Pathology review
Renal tubular defects: Pathology review
Renal tubular acidosis: Pathology review
Acid-base disturbances: Pathology review
Electrolyte disturbances: Pathology review
Renal failure: Pathology review
Nephrotic syndromes: Pathology review
Nephritic syndromes: Pathology review
Urinary incontinence: Pathology review
Urinary tract infections: Pathology review
Kidney stones: Pathology review
Renal and urinary tract masses: Pathology review
Multicystic dysplastic kidney
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Tanner Marshall, MS
Multicystic dysplastic kidney or MCDK is a congenital disease where one or both kidneys don’t form quite right, specifically causing them to not drain urine properly, which results in urine building up in the kidneys and forming multiple fluid-filled sacs called cysts.
Alright so during fetal development, first off you’ve got this structure called the mesonephric duct which is involved in development of urinary and reproductive organs, and during the 5th week of gestation, a little guy called the ureteric bud starts pushing its way into another structure called the metanephric blastema, and together, these two little embryologic structures go on to develop into a kidney.
At about the 7th week, nephrogenesis, or formation of the kidneys, starts under the influence of that ureteric bud.
By about 20 weeks, the ureteric bud has formed the ureters, the renal calyces, collecting ducts, and collecting tubules, while the metanephric blastema develops into the nephron itself, which includes the epithelial cells and the podocytes of Bowman’s capsule.
In the third trimester and throughout infancy, the kidneys continue to grow and mature.
Although not completely known, it’s thought that MCDK is a result of some sort of abnormal induction of the metanephric blastema by the ureteric bud.
This failure might be the fault of the mesonephric duct not forming right, or the ureteric bud not forming right, or both.
Regardless of the cause of failure, the ureteric bud is supposed to go on to form the ureters as well as the rest of the tubules that branch out to collect urine.
So as blood starts coming in to be filtered, and urine starts getting produced, a failure to properly develop into these urine-collecting tubules means that the urine has nowhere to go, and so it builds up in the kidneys and forms these fluid-filled cysts that are composed of abnormal connective tissue—especially cartilage—that actually replaces normal kidney tissue and decreases the kidney’s ability to function.
Multicystic dysplastic kidney (MCDK) is a congenital disorder in which the kidneys fail to develop normally and cannot drain urine properly. This causes urine to build up in the kidneys and forms multiple cysts.
MCDK is often detected during routine prenatal ultrasounds, or during early childhood with hydronephrosis and recurrent urinary tract infections of the affected kidneys.
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