Multiple myeloma




Multiple myeloma



Iron deficiency anemia



Sideroblastic anemia

Anemia of chronic disease

Lead poisoning

Hemolytic disease of the newborn

Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Autoimmune hemolytic anemia

Pyruvate kinase deficiency

Paroxysmal nocturnal hemoglobinuria

Sickle cell disease (NORD)

Hereditary spherocytosis

Anemia of chronic disease

Aplastic anemia

Fanconi anemia

Megaloblastic anemia

Folate (Vitamin B9) deficiency

Vitamin B12 deficiency

Fanconi anemia

Diamond-Blackfan anemia

Heme synthesis disorders

Acute intermittent porphyria

Porphyria cutanea tarda

Lead poisoning

Coagulation disorders


Vitamin K deficiency

Platelet disorders

Bernard-Soulier syndrome

Glanzmann's thrombasthenia

Hemolytic-uremic syndrome

Immune thrombocytopenic purpura

Thrombotic thrombocytopenic purpura

Mixed platelet and coagulation disorders

Von Willebrand disease

Disseminated intravascular coagulation

Heparin-induced thrombocytopenia

Thrombosis syndromes (hypercoagulability)

Antithrombin III deficiency

Factor V Leiden

Protein C deficiency

Protein S deficiency

Antiphospholipid syndrome


Hodgkin lymphoma

Non-Hodgkin lymphoma


Chronic leukemia

Acute leukemia

Leukemoid reaction

Leukemoid reaction

Dysplastic and proliferative disorders

Myelodysplastic syndromes

Polycythemia vera (NORD)

Myelofibrosis (NORD)

Essential thrombocythemia (NORD)

Langerhans cell histiocytosis

Mastocytosis (NORD)

Plasma cell dyscrasias

Multiple myeloma

Monoclonal gammopathy of undetermined significance

Waldenstrom macroglobulinemia

Hematological system pathology review

Microcytic anemia: Pathology review

Non-hemolytic normocytic anemia: Pathology review

Intrinsic hemolytic normocytic anemia: Pathology review

Extrinsic hemolytic normocytic anemia: Pathology review

Macrocytic anemia: Pathology review

Heme synthesis disorders: Pathology review

Coagulation disorders: Pathology review

Platelet disorders: Pathology review

Mixed platelet and coagulation disorders: Pathology review

Thrombosis syndromes (hypercoagulability): Pathology review

Lymphomas: Pathology review

Leukemias: Pathology review

Plasma cell disorders: Pathology review

Myeloproliferative disorders: Pathology review


Multiple myeloma


0 / 18 complete

USMLE® Step 1 questions

0 / 2 complete

High Yield Notes

6 pages


Multiple myeloma

of complete


USMLE® Step 1 style questions USMLE

of complete

A 65 year-old man comes to his primary care physician because of lower back pain, recurrent sinus infections, and 4 kg (8.8 lb) unintentional weight loss over the past three months. Past medical history is notable for osteoporosis and atherosclerosis. The patient consumes 4-5 glasses of wine per week and is sexually active with his spouse. His temperature is 36.8°C (98.2°F), blood pressure is 125/76 mmHg, pulse is 65/min, and respiratory rate is 15/min. Cardiac, pulmonary, and abdominal exams are normal. Pain is elicited with palpation of the lumbar spine. As part of the diagnostic work-up, a peripheral blood smear is ordered, and the results are as follows:
Image from Wikimedia

 Which of the following findings will provide a definitive diagnosis of the patient’s condition? 

External References

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multiple myeloma p. 438

Anemias p. 425-417

multiple myeloma p. 438

Bone lesions

multiple myeloma p. 438

Erythrocytes p. 415

multiple myeloma p. 438

IgA antibodies p. 103

multiple myeloma production of p. 438

IgG antibodies p. 103

multiple myeloma production of p. 438

Lytic bone lesions

multiple myeloma and p. 438

M protein

in multiple myeloma p. 438

Multiple myeloma p. 438

amyloidosis p. 216

common metastases p. 202

ESR in p. 212

lab/diagnostic findings p. 722

metastatic calcification p. 215

osteoporosis p. 472

as plasma cell cancer p. 412

Waldenström macroglobulinemia

multiple myeloma vs p. 438


Multiple myeloma is a type of cancer that affects the plasma cells in the bone marrow. It is characterized by an overgrowth of abnormal plasma cells, which can cause damage to the bones, weaken the immune system, and produce an excess of certain proteins in the blood. Symptoms of multiple myeloma may include bone pain, fatigue, anemia, kidney problems, and frequent infections.


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