Neonatal herpes simplex

Neonatal herpes simplex is a rare but serious condition, usually caused by vertical transmission of the virus during delivery. Mothers with active genital herpes lesions at term should undergo cesarean delivery. A typical sign is vesicular eruption of the skin, eyes, and mouth, which may be accompanied by or progress to disseminated disease. Diagnosis is by viral culture, PCR, immunofluorescence, or electron microscopy. Treatment is with high-dose parenteral acyclovir and supportive care.