Neonatal sepsis
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Notes
Neonatal sepsis
Pathology
Hypersensitivity reactions
Anaphylaxis
Asthma
Food allergy
Type I hypersensitivity
Autoimmune hemolytic anemia
Goodpasture syndrome
Graves disease
Hemolytic disease of the newborn
Myasthenia gravis
Pemphigus vulgaris
Rheumatic heart disease
Type II hypersensitivity
Poststreptococcal glomerulonephritis
Serum sickness
Systemic lupus erythematosus
Type III hypersensitivity
Contact dermatitis
Graft-versus-host disease
Type IV hypersensitivity
Immunodeficiences
Asplenia
Common variable immunodeficiency
Hyperimmunoglobulin E syndrome
IgG subclass deficiency
Isolated primary immunoglobulin M deficiency
Selective immunoglobulin A deficiency
X-linked agammaglobulinemia
Adenosine deaminase deficiency
Ataxia-telangiectasia
Hyper IgM syndrome
Severe combined immunodeficiency
Wiskott-Aldrich syndrome
Complement deficiency
Hereditary angioedema
Cytomegalovirus infection after transplant (NORD)
Post-transplant lymphoproliferative disorders (NORD)
Chediak-Higashi syndrome
Chronic granulomatous disease
Leukocyte adhesion deficiency
Immune system pathology review
Blood transfusion reactions and transplant rejection: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
Assessments
Neonatal sepsis
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Neonatal sepsis
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Summary
Neonatal sepsis is a serious condition in which bacteria and other germs enter the body and cause an infection in a neonate's bloodstream, in the setting of fever. Neonatal sepsis has two categories: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis presenting in the first 3 days of life. EOS is usually caused by Group B Streptococci or Escherichia coli, usually presenting itself as pneumonia. On the other hand, LOS presents itself after 3 days. LOS is usually caused by Staphylococcus and commonly manifests itself as meningitis.
Symptoms of neonatal sepsis may depend on the category, but they commonly include fever, irritability, difficulty feeding, and a poor overall appearance. In severe cases, neonatal sepsis can lead to organ failure and death.
Treatment for neonatal sepsis typically involves antibiotics to kill the bacteria causing the infection and supportive care, such as intravenous fluids, respiratory support, and medications to control symptoms like fever.
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