Neuroleptic malignant syndrome

Summary of Neuroleptic malignant syndrome
Neuroleptic malignant syndrome is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. The syndrome typically consists of muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium, and is associated with elevated plasma creatine phosphokinase. The incidence of neuroleptic malignant syndrome has decreased since it was first described, due to changes in prescribing habits, but it is still a potential danger to patients being treated with antipsychotic medication. Because of the unpredictability of neuroleptic malignant syndrome, treatment may vary substantially, but is generally based on supportive care and removal of the offending antipsychotic drug.

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Neuroleptic malignant syndrome

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Neuroleptic malignant syndrome

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Neuroleptic malignant syndrome is due to toxicity of (type) drugs.

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A 25-year-old man is brought to the emergency department by his roommate, who returned from a four-day trip to find him febrile, rigid, and delirious. The patient is unable to give his medical history, and his roommate knows only that he had changed his medication regimen a week ago due to significant weight gain on his previous medication. His vital signs are as follows: temperature 40.2°C (104.4°F), pulse 126/min, respirations 24/min, and blood pressure 135/96 mm Hg. No hyperreflexia or myoclonus is observed. Which of the following is the patient’s most likely chronic diagnosis?

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