Neuroleptic malignant syndrome
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Neuroleptic malignant syndrome
Psychological disorders
Anxiety disorders
Disorders originating in infancy or childhood
Eating disorders and impulse-control disorders
Factitious disorders
Medication-induced movement disorders and other adverse effects of medication
Mood disorders
Neurocognitive disorders
Personality disorders
Psychotic disorders
Sexual disorders and gender dysphoria
Somatic symptoms and related disorders
Substance use disorders
Psychological disorders review
Anxiety disorders, phobias and stress-related disorders: Pathology Review
Childhood and early-onset psychological disorders: Pathology review
Developmental and learning disorders: Pathology review
Eating disorders: Pathology review
Mood disorders: Pathology review
Personality disorders: Pathology review
Trauma- and stress-related disorders: Pathology review
Schizophrenia spectrum disorders: Pathology review
Malingering, factitious disorders and somatoform disorders: Pathology review
Drug misuse, intoxication and withdrawal: Alcohol: Pathology review
Drug misuse, intoxication and withdrawal: Hallucinogens: Pathology review
Drug misuse, intoxication and withdrawal: Other depressants: Pathology review
Drug misuse, intoxication and withdrawal: Stimulants: Pathology review
Amnesia, dissociative disorders and delirium: Pathology review
Dementia: Pathology review
Psychiatric emergencies: Pathology review
Psychological sleep disorders: Pathology review
Assessments
Flashcards
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USMLE® Step 1 questions
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High Yield Notes
10 pages



Flashcards
Neuroleptic malignant syndrome
0 of 11 complete
Questions
USMLE® Step 1 style questions USMLE
0 of 1 complete
A 23-year-old man is brought to the emergency department after collapsing at a music festival on a hot summer day. The patient was with friends at an electronic dance show. According to his friends, the patient consumed a powdered drug at the concert. Afterwards, while dancing, he suddenly collapsed and started having tremors in the upper and lower extremities. He has a past medical history of depression, anxiety, and bipolar disorder, for which he takes fluoxetine, alprazolam as needed, and aripiprazole. Temperature is 39.0°C (102.2 °F), pulse is 132/min, respirations are 24/min, blood pressure is 172/85 mmHg, and O2 saturation is 97% on room air. On physical examination the patient is diaphoretic, mumbling incoherent sounds, and will not lie still in the gurney. The patient has increased muscle tone. Brief, sudden jerks are present throughout the upper and lower extremities. Which of the following clinical features is most specific to this patient's clinical presentation?
External References
First Aid
2024
2023
2022
2021
Fever
neuroleptic malignant syndrome p. 587
Neuroleptic malignant syndrome (NMS) p. 567, 587
Summary
Neuroleptic malignant syndrome is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs, which are used to treat mental health conditions, such as schizophrenia, bipolar disorder, and severe depression. Neuroleptic malignant syndrome typically presents with muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium.