Neuroleptic malignant syndrome
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Neuroleptic malignant syndrome
Psychiatry
Psychiatry
Mood disorders: Clinical
Anxiety disorders: Clinical
Schizophrenia spectrum disorders: Clinical
Dissociative disorders: Clinical
Eating disorders: Clinical
Obsessive compulsive disorders: Clinical
Trauma- and stressor-related disorders: Clinical
Disruptive, impulse-control and conduct disorders: Clinical
Personality disorders: Clinical
Sleep disorders: Clinical
Somatic symptom disorders: Clinical
Sexual dysfunctions: Clinical
Paraphilic disorders: Clinical
Dementia and delirium: Clinical
Toxidromes: Clinical
Medication overdoses and toxicities: Pathology review
Environmental and chemical toxicities: Pathology review
Substance misuse and addiction: Clinical
Drug misuse, intoxication and withdrawal: Hallucinogens: Pathology review
Psychiatric emergencies: Pathology review
Schizophrenia spectrum disorders: Pathology review
Drug misuse, intoxication and withdrawal: Stimulants: Pathology review
Drug misuse, intoxication and withdrawal: Alcohol: Pathology review
Selective serotonin reuptake inhibitors
Serotonin and norepinephrine reuptake inhibitors
Tricyclic antidepressants
Monoamine oxidase inhibitors
Atypical antidepressants
Typical antipsychotics
Atypical antipsychotics
Lithium
Nonbenzodiazepine anticonvulsants
Anticonvulsants and anxiolytics: Barbiturates
Anticonvulsants and anxiolytics: Benzodiazepines
Psychomotor stimulants
Opioid agonists, mixed agonist-antagonists and partial agonists
Opioid antagonists
ADHD: Information for patients and families (The Primary School)
Attention deficit hyperactivity disorder
Autism spectrum disorder
Neurodevelopmental disorders: Clinical
Major depressive disorder
Suicide
Bipolar and related disorders
Major depressive disorder with seasonal pattern
Premenstrual dysphoric disorder
Generalized anxiety disorder
Social anxiety disorder
Panic disorder
Agoraphobia
Phobias
Obsessive-compulsive disorder
Body focused repetitive disorders
Body dysmorphic disorder
Post-traumatic stress disorder
Physical and sexual abuse
Schizoaffective disorder
Schizophreniform disorder
Delusional disorder
Schizophrenia
Delirium
Amnesia
Dissociative disorders
Anorexia nervosa
Bulimia nervosa
Cluster A personality disorders
Cluster B personality disorders
Cluster C personality disorders
Somatic symptom disorder
Factitious disorder
Tobacco dependence
Opioid dependence
Cannabis dependence
Cocaine dependence
Alcohol use disorder
Bruxism
Nocturnal enuresis
Insomnia
Night terrors
Narcolepsy (NORD)
Erectile dysfunction
Male hypoactive sexual desire disorder
Orgasmic dysfunction
Female sexual interest and arousal disorder
Genito-pelvic pain and penetration disorder
Disruptive, impulse control, and conduct disorders
Learning disability
Fetal alcohol syndrome
Tourette syndrome
Rett syndrome
Shaken baby syndrome
Enuresis
Encopresis
Serotonin syndrome
Neuroleptic malignant syndrome
Mood disorders: Pathology review
Amnesia, dissociative disorders and delirium: Pathology review
Personality disorders: Pathology review
Eating disorders: Pathology review
Psychological sleep disorders: Pathology review
Malingering, factitious disorders and somatoform disorders: Pathology review
Trauma- and stress-related disorders: Pathology review
Developmental and learning disorders: Pathology review
Childhood and early-onset psychological disorders: Pathology review
Vascular dementia
Frontotemporal dementia
Dementia: Pathology review
Alzheimer disease
Assessments
Flashcards
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USMLE® Step 1 questions
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High Yield Notes
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Flashcards
Neuroleptic malignant syndrome
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Questions
USMLE® Step 1 style questions USMLE
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A 23-year-old man is brought to the emergency department after collapsing at a music festival on a hot summer day. The patient was with friends at an electronic dance show. According to his friends, the patient consumed a powdered drug at the concert. Afterwards, while dancing, he suddenly collapsed and started having tremors in the upper and lower extremities. He has a past medical history of depression, anxiety, and bipolar disorder, for which he takes fluoxetine, alprazolam as needed, and aripiprazole. Temperature is 39.0°C (102.2 °F), pulse is 132/min, respirations are 24/min, blood pressure is 172/85 mmHg, and O2 saturation is 97% on room air. On physical examination the patient is diaphoretic, mumbling incoherent sounds, and will not lie still in the gurney. The patient has increased muscle tone. Brief, sudden jerks are present throughout the upper and lower extremities. Which of the following clinical features is most specific to this patient's clinical presentation?
External References
First Aid
2024
2023
2022
2021
Fever
neuroleptic malignant syndrome p. 587
Neuroleptic malignant syndrome (NMS) p. 567, 587
Summary
Neuroleptic malignant syndrome is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs, which are used to treat mental health conditions, such as schizophrenia, bipolar disorder, and severe depression. Neuroleptic malignant syndrome typically presents with muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium.