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non-Hodgkin lymphoma p. 436
non-Hodgkin lymphoma and p. 436
non-Hodgkin vs p. 436
non-Hodgkin lymphoma p. 437
non-Hodgkin p. 436, 437
associations p. 730
corticosteroids p. 118
Hashimoto thyroiditis and p. 347
hepatitis C p. 170
HIV-positive adults p. 174
Hodgkin lymphoma vs p. 436
oncogenes and p. 222
rituximab for p. 120, 450
vinca alkaloids for p. 449
The term non-Hodgkin lymphoma, sometimes called NHL, can be broken down. Lymph- refers to lymphocytes and oma- refers to a tumor.
The naive B cells then leave the bone marrow and circulate in the blood and eventually settle down in lymph nodes.
B-cells differentiate into plasma cells, which are found in the medulla or center of the lymph node.
Plasma cells release antibodies or immunoglobulins.
Antibodies bind to pathogens like viruses and bacteria, to help destroy or remove them.
In fact, the combination of surface proteins that are on an immune cell works a bit like an ID card.
Now, a B cell is activated when it encounters an antigen that binds just perfectly to its surface immunoglobulin.
Non-Hodgkin lymphomas are a group of blood cancers that include any kind of lymphoma except Hodgkin's lymphomas. Hodgkin's lymphoma is characterized by the presence of a specific type of cell called a Reed-Sternberg cell. A lymphoma that lacks this specific cell, is a non-Hodgkin lymphoma. Non-Hodgkin lymphomas can originate from B cells or T cells, though they most commonly arise from B cells.
Symptoms of non-Hodgkin lymphomas include enlarged lymph nodes, fever, night sweats, weight loss, and fatigue. Other symptoms may include bone pain, chest pain, or itchiness. Some forms are slow growing while others are fast-growing. Treatment usually involves chemotherapy and radiation therapy, depending on the lymphoma subtype, aggressivity, and how far it has spread.
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