AssessmentsNormal pressure hydrocephalus
Normal pressure hydrocephalus
USMLE® Step 1 style questions USMLE
USMLE® Step 2 style questions USMLE
A 69-year-old woman comes to the clinic with her daughter because of memory loss and increased falls. Her daughter notes that these symptoms have been gradually worsening over the last year. She has had several falls within the past 6 months, but has had no major injuries. Her only other symptom is urinary urgency, with occasional urinary incontinence. Her past medical history includes hypertension, hyperlipidemia, and hypothyroidism, all of which are well-controlled on medications. Physical examination shows a shuffling, magnetic gait. The patient scores a 23 on a 30-point scale on the mini-mental status examination. TSH and free T4 are within normal limits and urinalysis is negative. Which of the following would most likely be seen on a brain MRI?
Hydrocephalus, which is also termed as “water on the brain”, is an excessive buildup of cerebrospinal fluid within the brain.
Even though the pressure on lumbar puncture is expected to be increased, in this case, it’s normal, which is why it’s termed as “normal pressure” hydrocephalus.
The choroid plexus is made up of ependymal cells which produces cerebrospinal fluid - a fluid that helps provide buoyancy and protection, as well as metabolic fuel for the brain.
Highest up, are two C-shaped lateral ventricles that lie deep in each cerebral hemisphere.
The two lateral ventricles drain their cerebrospinal fluid into the third ventricle, which is a narrow, funnel-shaped, cavity at the center of the brain.
It looks a bit like little fingers poking through, and these protrusions are called arachnoid granulations.
The pressure within the subarachnoid space is higher than the pressure in the dural sinus, so CSF flows through the arachnoid granulations is only in one direction.
Normal pressure hydrocephalus develops when cerebrospinal fluid is unable to get through those arachnoid granulations normally.
This process develops gradually and most commonly affects the elderly.
There are two types of normal pressure hydrocephalus.
The first type is an primary normal pressure hydrocephalus, where the cause is idiopathic or unknown.
The second type is secondary normal pressure hydrocephalus, where the cause is damage to the arachnoid villi which disrupts CSF reabsorption.