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Amyotrophic lateral sclerosis
von Hippel-Lindau disease
Acoustic neuroma (schwannoma)
Adult brain tumors
Pediatric brain tumors
Transient ischemic attack
Cavernous sinus thrombosis
Spinocerebellar ataxia (NORD)
Tethered spinal cord syndrome
Lewy body dementia
Normal pressure hydrocephalus
Acute disseminated encephalomyelitis
Central pontine myelinolysis
JC virus (Progressive multifocal leukoencephalopathy)
Idiopathic intracranial hypertension
Opsoclonus myoclonus syndrome (NORD)
Restless legs syndrome
Early infantile epileptic encephalopathy (NORD)
Cauda equina syndrome
Treponema pallidum (Syphilis)
Vitamin B12 deficiency
Concussion and traumatic brain injury
Spinal muscular atrophy
Carpal tunnel syndrome
Thoracic outlet syndrome
Lambert-Eaton myasthenic syndrome
Adult brain tumors: Pathology review
Central nervous system infections: Pathology review
Cerebral vascular disease: Pathology review
Congenital neurological disorders: Pathology review
Dementia: Pathology review
Demyelinating disorders: Pathology review
Headaches: Pathology review
Movement disorders: Pathology review
Neurocutaneous disorders: Pathology review
Neuromuscular junction disorders: Pathology review
Pediatric brain tumors: Pathology review
Seizures: Pathology review
Spinal cord disorders: Pathology review
Traumatic brain injury: Pathology review
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Opsoclonus-myoclonus syndrome is also called OMS or dancing eyes-dancing feet syndrome.
Opsoclonus describes seemingly random, involuntary, and rapid eye movements in the horizontal, vertical, and diagonal directions.
Myoclonus describes lightening-like limb movements or limb jerks, that can also be more tremulous.
The syndrome also causes ataxia, which often results in the inability to walk, sit or crawl, and the loss of previously attained abilities, like speech.
Generally speaking, OMS is thought to be an autoimmune condition in which the body attacks the nervous system, resulting in the characteristic signs and symptoms.
The precise cause of OMS is unknown, but in children, it’s often due to a paraneoplastic syndrome.
The idea is that a hidden or occult tumor - like a neuroblastoma or ganglioneuroblastoma - triggers the body’s immune system, and the resulting antibodies unintentionally target healthy cells of the nervous system.
CD20+ B-cells that get into the CSF fluid seem to play an important role.
One brain area that gets affected is the cerebellum, which plays an important role in coordinating body movements.
In older children and adolescents OMS is thought to be triggered by an infection, and in adults, it’s often due to a paraneoplastic process due to lung or breast cancer, for example.
In children with OMS, there’s almost always ataxia, so it’s sometimes referred to as OMAS - with the A representing ataxia.
In fact, most toddlers with OMS are initially misdiagnosed with acute cerebellar ataxia of childhood.
The diagnosis of OMS is also often based on symptoms like opsoclonus and myoclonus which can appear abruptly, progressing over days to weeks.
Opsoclonus-myoclonus syndrome (OMS) is a rare condition, characterized by rapid, uncontrolled eye movements (opsoclonus) and sudden twitching or jerking of muscles (myoclonus). It can also present with ataxia, which often results in the inability to walk, sit or crawl, and the loss of previously attained abilities, like speech.
The cause of OMS is not well understood, but it is thought to be due to an autoimmune condition in which the body attacks the nervous system, resulting in characteristic signs and symptoms. Treatment involves immunosuppressive therapy like corticosteroids, intravenous immunoglobulin or IVIG, drugs like cyclophosphamide, and rituximab.
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