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Ortopedia 2020!
Introduction to biostatistics
Probability
Types of data
Mean, median, and mode
Range, variance, and standard deviation
Normal distribution and z-scores
Standard error of the mean (Central limit theorem)
Paired t-test
Two-sample t-test
Hypothesis testing: One-tailed and two-tailed tests
Sensitivity and specificity
Positive and negative predictive value
Test precision and accuracy
Incidence and prevalence
Relative and absolute risk
Odds ratio
Attributable risk (AR)
Mortality rates and case-fatality
DALY and QALY
Direct standardization
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Ecologic study
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Placebo effect and masking
Disease causality
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Confounding
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Modes of infectious disease transmission
Outbreak investigations
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Vaccination and herd immunity
Correlation
Linear regression
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Type I and type II errors
Inflammation
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Oncogenes and tumor suppressor genes
Metaplasia and dysplasia
Epigenetics
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Introduction to the immune system
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Innate immune system
Complement system
B-cell development
T-cell development
Cytokines
Antibody classes
B-cell activation and differentiation
Somatic hypermutation and affinity maturation
T-cell activation
VDJ rearrangement
MHC class I and MHC class II molecules
Cell-mediated immunity of CD4 cells
Cell-mediated immunity of natural killer and CD8 cells
Contracting the immune response and peripheral tolerance
B- and T-cell memory
Type I hypersensitivity
Food allergy
Anaphylaxis
Type II hypersensitivity
Serum sickness
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Graft-versus-host disease
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Chronic granulomatous disease
Leukocyte adhesion deficiency
Complement deficiency
X-linked agammaglobulinemia
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Selective immunoglobulin A deficiency
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Thymic aplasia
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Adenosine deaminase deficiency
Glucocorticoids
Non-corticosteroid immunosuppressants and immunotherapies
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus saprophyticus
Streptococcus pneumoniae
Streptococcus pyogenes (Group A Strep)
Streptococcus agalactiae (Group B Strep)
Streptococcus viridans
Enterococcus
Clostridium perfringens
Clostridium botulinum (Botulism)
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Listeria monocytogenes
Bacillus anthracis (Anthrax)
Bacillus cereus (Food poisoning)
Corynebacterium diphtheriae (Diphtheria)
Nocardia
Actinomyces israelii
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Salmonella (non-typhoidal)
Salmonella typhi (typhoid fever)
Pseudomonas aeruginosa
Enterobacter
Bartonella henselae (Cat-scratch disease and Bacillary angiomatosis)
Klebsiella pneumoniae
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Proteus mirabilis
Yersinia enterocolitica
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Bacteroides fragilis
Yersinia pestis (Plague)
Helicobacter pylori
Vibrio cholerae (Cholera)
Campylobacter jejuni
Neisseria meningitidis
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Moraxella catarrhalis
Francisella tularensis (Tularemia)
Bordetella pertussis (Pertussis/Whooping cough)
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Pasteurella multocida
Mycobacterium tuberculosis (Tuberculosis)
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Treponema pallidum (Syphilis)
Leptospira
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Borrelia species (Relapsing fever)
Rickettsia rickettsii (Rocky Mountain spotted fever) and other Rickettsia species
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Ehrlichia and Anaplasma
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Adenovirus
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Viral hepatitis: Pathology review
Hepatitis D virus
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Poxvirus (Smallpox and Molluscum contagiosum)
JC virus (Progressive multifocal leukoencephalopathy)
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Coxsackievirus
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Viral hepatitis: Pathology review
Influenza virus
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Viral hepatitis: Pathology review
Norovirus
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Prions (Spongiform encephalopathy)
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Protein synthesis inhibitors: Aminoglycosides
Antimetabolites: Sulfonamides and trimethoprim
Antituberculosis medications
Miscellaneous cell wall synthesis inhibitors
Cell wall synthesis inhibitors: Cephalosporins
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DNA synthesis inhibitors: Fluoroquinolones
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Heart failure: Pathology review
Aortic dissections and aneurysms: Pathology review
Cyanotic congenital heart defects: Pathology review
Cardiac and vascular tumors: Pathology review
Endocarditis: Pathology review
Vasculitis: Pathology review
Heart blocks: Pathology review
Cardiomyopathies: Pathology review
Dyslipidemias: Pathology review
Deep vein thrombosis and pulmonary embolism: Pathology review
Pericardial disease: Pathology review
Hypertension: Pathology review
Coronary artery disease: Pathology review
Acyanotic congenital heart defects: Pathology review
Peripheral artery disease: Pathology review
Platelet disorders: Pathology review
Mixed platelet and coagulation disorders: Pathology review
Coagulation disorders: Pathology review
Non-hemolytic normocytic anemia: Pathology review
Macrocytic anemia: Pathology review
Microcytic anemia: Pathology review
Extrinsic hemolytic normocytic anemia: Pathology review
Myeloproliferative disorders: Pathology review
Leukemias: Pathology review
Plasma cell disorders: Pathology review
Lymphomas: Pathology review
Intrinsic hemolytic normocytic anemia: Pathology review
Thrombosis syndromes (hypercoagulability): Pathology review
Pancreatitis: Pathology review
Cirrhosis: Pathology review
Appendicitis: Pathology review
Malabsorption syndromes: Pathology review
Gastrointestinal bleeding: Pathology review
Gallbladder disorders: Pathology review
Colorectal polyps and cancer: Pathology review
Esophageal disorders: Pathology review
Congenital gastrointestinal disorders: Pathology review
GERD, peptic ulcers, gastritis, and stomach cancer: Pathology review
Diverticular disease: Pathology review
Jaundice: Pathology review
Sjogren syndrome: Pathology review
Scleroderma: Pathology review
Bone tumors: Pathology review
Systemic lupus erythematosus (SLE): Pathology review
Neuromuscular junction disorders: Pathology review
Bone disorders: Pathology review
Gout and pseudogout: Pathology review
Myalgias and myositis: Pathology review
Back pain: Pathology review
Skeletal system anatomy and physiology
Cartilage structure and growth
Bone remodeling and repair
Fibrous, cartilage, and synovial joints
Muscular system anatomy and physiology
Muscle contraction
Slow twitch and fast twitch muscle fibers
Sliding filament model of muscle contraction
Neuromuscular junction and motor unit
Rheumatoid arthritis
Reactive arthritis
Psoriatic arthritis
Gout
Calcium pyrophosphate deposition disease (pseudogout)
Ankylosing spondylitis
Juvenile idiopathic arthritis
Systemic lupus erythematosus
Scleroderma
Raynaud phenomenon
Limited systemic sclerosis (CREST syndrome)
Sjogren syndrome
Fibromyalgia
Mixed connective tissue disease
Polymyalgia rheumatica
Amyloidosis
Dermatomyositis
Polymyositis
Inclusion body myopathy
Osteoarthritis
Slipped capital femoral epiphysis
Paget disease of bone
Osteomalacia and rickets
Osteoporosis
Osgood-Schlatter disease (traction apophysitis)
Legg-Calve-Perthes disease
Septic arthritis
Osteomyelitis
Lordosis, kyphosis, and scoliosis
Rotator cuff tear
Meniscus tear
Compartment syndrome
Bone tumors
Developmental dysplasia of the hip
Cleidocranial dysplasia
Achondroplasia
Acetaminophen (Paracetamol)
Antigout medications
Non-steroidal anti-inflammatory drugs
Osteoporosis medications
Nephrotic syndromes: Pathology review
Renal and urinary tract masses: Pathology review
Urinary incontinence: Pathology review
Renal failure: Pathology review
Renal tubular acidosis: Pathology review
Congenital renal disorders: Pathology review
Urinary tract infections: Pathology review
Kidney stones: Pathology review
Nephritic syndromes: Pathology review
Renal tubular defects: Pathology review
Acid-base disturbances: Pathology review
Pediatric brain tumors: Pathology review
Movement disorders: Pathology review
Headaches: Pathology review
Adult brain tumors: Pathology review
Vertigo: Pathology review
Neurocutaneous disorders: Pathology review
Central nervous system infections: Pathology review
Seizures: Pathology review
Demyelinating disorders: Pathology review
Traumatic brain injury: Pathology review
Congenital neurological disorders: Pathology review
Parathyroid disorders and calcium imbalance: Pathology review
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Diabetes insipidus and SIADH: Pathology review
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Multiple endocrine neoplasia: Pathology review
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Complications during pregnancy: Pathology review
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Lung cancer and mesothelioma: Pathology review
Nasal, oral and pharyngeal diseases: Pathology review
Obstructive lung diseases: Pathology review
Coronary artery disease: Clinical (To be retired)
Heart failure: Clinical (To be retired)
Syncope: Clinical (To be retired)
Hypertension: Clinical (To be retired)
Pericardial disease: Clinical (To be retired)
Infective endocarditis: Clinical (To be retired)
Valvular heart disease: Clinical (To be retired)
Cardiomyopathies: Clinical (To be retired)
Hypercholesterolemia: Clinical (To be retired)
Aortic aneurysms and dissections: Clinical (To be retired)
Asthma: Clinical (To be retired)
Chronic obstructive pulmonary disease (COPD): Clinical (To be retired)
Diffuse parenchymal lung disease: Clinical (To be retired)
Acute respiratory distress syndrome: Clinical (To be retired)
Pleural effusion: Clinical (To be retired)
Lung cancer: Clinical (To be retired)
Pneumonia: Clinical (To be retired)
Venous thromboembolism: Clinical (To be retired)
Anemia: Clinical (To be retired)
Leukemia: Clinical (To be retired)
Lymphoma: Clinical (To be retired)
Thrombocytopenia: Clinical (To be retired)
Blood products and transfusion: Clinical (To be retired)
Thrombophilia: Clinical (To be retired)
Bleeding disorders: Clinical (To be retired)
Myeloproliferative neoplasms: Clinical (To be retired)
Plasma cell disorders: Clinical (To be retired)
Diabetes mellitus: Clinical (To be retired)
Hyperthyroidism: Clinical (To be retired)
Hypothyroidism and thyroiditis: Clinical (To be retired)
Thyroid nodules and thyroid cancer: Clinical (To be retired)
MEN syndromes: Clinical (To be retired)
Cushing syndrome: Clinical (To be retired)
Adrenal masses and tumors: Clinical (To be retired)
Pituitary adenomas and pituitary hyperfunction: Clinical (To be retired)
Hypopituitarism: Clinical (To be retired)
Adrenal insufficiency: Clinical (To be retired)
Systemic lupus erythematosus (SLE): Clinical (To be retired)
Rheumatoid arthritis: Clinical (To be retired)
Joint pain: Clinical (To be retired)
Seronegative arthritis: Clinical (To be retired)
Vasculitis: Clinical (To be retired)
Inflammatory myopathies: Clinical (To be retired)
Sjogren syndrome: Clinical (To be retired)
Gallbladder disorders: Clinical (To be retired)
Esophagitis: Clinical (To be retired)
Esophageal disorders: Clinical (To be retired)
Gastroesophageal reflux disease (GERD): Clinical (To be retired)
Peptic ulcers and stomach cancer: Clinical (To be retired)
Diarrhea: Clinical (To be retired)
Malabsorption: Clinical (To be retired)
Inflammatory bowel disease: Clinical (To be retired)
Gastroparesis: Clinical (To be retired)
Colorectal cancer: Clinical (To be retired)
Diverticular disease: Clinical (To be retired)
Pancreatitis: Clinical (To be retired)
Gastrointestinal bleeding: Clinical (To be retired)
Viral hepatitis: Clinical (To be retired)
Jaundice: Clinical (To be retired)
Cirrhosis: Clinical (To be retired)
Hyponatremia: Clinical (To be retired)
Hypernatremia: Clinical (To be retired)
Hyperkalemia: Clinical (To be retired)
Hypokalemia: Clinical (To be retired)
Acute kidney injury: Clinical (To be retired)
Chronic kidney disease: Clinical (To be retired)
Kidney stones: Clinical (To be retired)
Metabolic and respiratory acidosis: Clinical (To be retired)
Renal cysts and cancer: Clinical (To be retired)
Urinary tract infections: Clinical (To be retired)
Parathyroid conditions and calcium imbalance: Clinical (To be retired)
Nephritic and nephrotic syndromes: Clinical (To be retired)
Stroke: Clinical (To be retired)
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Seizures: Clinical (To be retired)
Headaches: Clinical (To be retired)
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Methods of regression analysis
Study designs
Prevention
Eczematous rashes: Clinical (To be retired)
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Blistering skin disorders: Clinical (To be retired)
Autoimmune bullous skin disorders: Clinical (To be retired)
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Osgood-Schlatter disease (traction apophysitis)
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Evode Iradufasha, MD
Marisa Pedron
Tanner Marshall, MS
Osgood-Schlatter disease is an inflammation of the patellar ligament, right at the point where it inserts on the tibial tuberosity, resulting in painful swelling just below the knee.
It’s named after two orthopedic surgeons; the American Robert Osgood, and the Swiss Carl Schlatter.
So focusing in on the knee, the proximal epiphysis of the tibia, which is the upper end of the tibia that contributes to the knee joint, has a bony prominence called the tibial tuberosity.
This is considered an apophysis, meaning that it’s a bony prominence that serves as a site for tendon attachment.
The tibial tuberosity specifically serves as the attachment site for the patellar ligament, which is an extension of the quadriceps muscle tendon.
When the patellar ligament contracts, it extends the knee.
At birth, the proximal epiphysis consists of cartilage, but it contains an ossification center inside.
This ossification center begins to ossify or turn to bone between the ages of nine and fifteen, and becomes a bony tuberosity around the age of eighteen.
Osgood-Schlatter disease typically develops between the ages of nine and fifteen years old when the tuberosity hasn’t ossified yet, and therefore isn’t hard enough to resist traction of the patellar ligament.
So, this is why the disease is very common in young adolescents who play sports requiring the quadriceps muscles to contract repetitively, causing the patellar ligament to excessively strain on the not-yet-ossified tibial tuberosity.
This results in inflammation of the ligament at the point it inserts to the tuberosity, what is known as traction apophysitis.
Osgood-Schlatter disease is a common condition that affects the knee in adolescents, typically during the growth spurt that occurs just before puberty. It is caused by repetitive traction of the patella ligament on the tibial tuberosity, causing it to become inflamed, which results in a painful swelling just under the knee.
People with Osgood-Schlatter disease with a palpable lump below the knee, which gets very painful with physical activities like running, jumping, squatting, and especially when going up or down stairs, or when the knee gets hit by something. The treatment consists of reducing physical activity and applying ice to the tuberosity to reduce swelling, as well as pain medication. Rarely, surgery may be necessary, especially if fragmented bones have avulsed off, and get trapped within the patella ligament.
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