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Renal system anatomy and physiology
Body fluid compartments
Movement of water between body compartments
TF/Px ratio and TF/Pinulin
Measuring renal plasma flow and renal blood flow
Regulation of renal blood flow
Tubular reabsorption and secretion
Tubular secretion of PAH
Tubular reabsorption of glucose
Tubular reabsorption and secretion of weak acids and bases
Proximal convoluted tubule
Loop of Henle
Distal convoluted tubule
Phosphate, calcium and magnesium homeostasis
Kidney countercurrent multiplication
Free water clearance
Physiologic pH and buffers
Buffering and Henderson-Hasselbalch equation
The role of the kidney in acid-base balance
Acid-base map and compensatory mechanisms
Plasma anion gap
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Sam Gillespie, BSc
Tanner Marshall, MS
Osmoregulation refers to the regulation of body fluid solute concentrations.
Solute concentrations are measured in osmolarity, usually mOsm/L, which is the number of osmoles within a litre of solution.
Now remember that an osmole refers to the individual ions within a solution. For example, a solution of 1 mmol/L of a salt like NaCl which can split apart in water to become Na+ and Cl- will have both Na+ and Cl- contribute to the osmolarity. So 1 mmol/L of NaCl is 2 mOsm/L.
In a normal body, blood plasma osmolarity is very tightly regulated and kept at around 290 to 300 mOsm/L.
The main components of this osmolarity is made up of ions like sodium, glucose, and urea.
To get the actual osmolarity of the body, a calculation like this one can be used: = 2[Na+] + [Glucose]/18 + [ BUN ]/2.8, where [Glucose] and [BUN] are measured in mg/dL.
Both glucose and BUN can be converted from mg/dl to mOsm/L by dividing them by 18 and 2.8 respectively.
Let’s say that it's a super sunny day out and you forget to bring water with you. Well first, as you walk around, you’re constantly losing water through sweat as well as water vapor from your mouth and nose as you breathe out - these are insensible water losses. Without drinking water, you can quickly get dehydrated.
This causes your plasma osmolarity to increase, because the fluid levels in your blood drop, but the total number of solute particles in remains roughly the same.
Two things now begin to happen simultaneously. First, a region in the brain called the anterior hypothalamus has a cluster of neurons called supraoptic nuclei, which have osmoreceptors that sense even tiny changes in osmolarity, as small as 1 mOsm/L. These neurons are always sampling the blood that passes by.
With increases in plasma osmolarity, water will flow out of the cell causing it to contract.
Increases in osmolarity past the normal set point of 290 to 300 mOsm/L stimulates the hypothalamus to produce antidiuretic hormone or ADH - also called vasopressin.
Second, as the blood volume drops, so does the blood pressure.
Specialized neurons, called baroreceptors, act as pressure sensors in the walls of the cardiovascular system - in a few specific areas. They’re in the posterior wall of the right atria of the heart, in the aortic arch, and in the right and left carotid sinuses, which is where the common carotid splits to become the internal and external carotid.
Osmoregulation is the process by which an organism regulates its internal body water-solute concentrations. It is a crucial aspect of maintaining the proper balance of water and electrolytes in the body, as electrolytes such as sodium, potassium, and chloride are dissolved in water, and a change in their concentrations can affect various physiological processes in the body. Solute concentrations are measured in osmolarity (mOsm/L), which is the number of osmoles within a liter of solution.
In humans, the osmolarity of blood plasma in the body is normally kept around 290 to 300 mOsm/L and is tightly controlled by antidiuretic hormone (ADH). With ADH secretion, the kidney increases the reabsorption of water back into circulation and causes vasoconstriction to bring up blood pressure. These pathways are controlled by negative feedback loops which inhibit further secretion of ADH.
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