Diuretics are a class of drugs used to reduce the amount of water in the body, by raising the production of urine. Once filtered in the glomerulus, osmotic diuretics do not get reabsorbed. This increases the osmotic pressure in the kidneys and causes water to leave blood into the forming urine. The main effect of osmotic diuretics is applied in parts of the nephron that are permeable to water, mainly the proximal tubule, descending part of the loop, and the collecting tubules. Examples of osmotic diuretics include mannitol, glycerin, and isosorbide.
- "Katzung & Trevor's Pharmacology Examination and Board Review,12th Edition" McGraw-Hill Education / Medical (2018)
- "Rang and Dale's Pharmacology" Elsevier (2019)
- "Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition" McGraw-Hill Education / Medical (2017)
- "Diuretics in acute kidney injury" Minerva Anestesiol (2009)
- "Inhaled mannitol for cystic fibrosis" Cochrane Database of Systematic Reviews (2018)
- "Sodium Glucose Cotransporter-2 Inhibition in Heart Failure" Circulation (2017)