AssessmentsOsteomalacia and rickets
Osteomalacia and rickets
Rickets can usually be treated with supplemental vitamin D and .
USMLE® Step 1 style questions USMLE
A 2-year-old African American boy is brought to the clinic by his mother with bone pain and difficulty walking for the past month. Physical examination shows a soft skull with frontal bossing, bumps along the costochondral junction, short stature, and bowing of the legs. X-rays show epiphyseal widening and metaphyseal cupping. His mother says that the child has been exclusively breastfed. Which of the following best describes the most likely serum laboratory values?
Inadequate bone mineralization could be due to a deficient or impaired metabolism of vitamin D, phosphate or calcium.
But first, a bit about bones. Now, long bones, like the femur, are made up of two epiphyses, which are its ends, and the diaphysis, which is the shaft.
Between each epiphysis and the diaphysis, there’s a region called the metaphysis.
And the metaphysis contains the epiphyseal plate, or the growth plate, which is the part of the bone that grows during childhood.
Once growth stops, the growth plate is replaced by an epiphyseal line, and this is known as epiphyseal closure.
Now, for bones to grow and develop properly, special bone cells, called osteoblasts, are hard at work.
To build bone, osteoblasts secrete osteoid, which is an organic matrix made of type 1 collagen.
These collagen fibers are the framework for the osteoblasts' work.
Osteoblasts then deposit calcium and phosphate crystals into the framework.
This process is called bone mineralization, and it confers strength to the growing bones.
Bone mineralization is dependent on an enzyme called alkaline phosphatase - which increases in response to osteoblast activity.
So, at the end of the day, bones are like a storage warehouse for calcium and phosphate.
Secondly, vitamin D must become metabolically active, and this process also has two steps.
Calcitriol increase renal tubular reabsorption of calcium which reduces the loss of calcium in the urine.
Calcitriol also increases the intestinal absorption of calcium and phosphate.
Ok, now let’s have a quick look at parathyroid hormone. Parathyroid hormone is secreted in response to low blood calcium levels, and it stimulates the resorption of calcium and a small amount of phosphate from the bone and into the bloodstream.
Lastly, parathyroid hormone increases calcium reabsorption and reduces the reabsorption of phosphate from the kidneys, so more phosphate is excreted through the urine.
Now, when there's not enough active vitamin D, calcium or phosphate, there's inadequate mineralization.
This means that osteoblasts don’t have enough calcium and phosphate to deposit into the organic matrix.
In children, because the growth plates haven’t closed yet, this leads to softening of the bones, impaired growth of bones, and bone malformations.
Whereas, in adults, where the epiphyseal plates have already closed, it only causes weakening and softening of bones which makes them easier to fracture.