Oxytocin and prolactin

Oxytocin and prolactin are two hormones that are mostly involved in the production and release of milk from the breasts during the nursing period. Prolactin - pro meaning “for” and “lactin” referring to milk - it stimulates the production of milk.

Oxytocin, on the other hand, makes the smooth muscle cells around the glands in the breasts contract so that they release the milk.

Oxytocin also helps the muscle in the uterus contract during labor. Both of these hormones are synthesized all the way up in the brain, by two interconnected structures – the hypothalamus and the pituitary gland.

So, basically, the hypothalamus is a part of the brain made up of several nuclei – or clusters of neurons.

Two of these nuclei, the paraventricular and supraoptic nuclei, contain neurons that secrete oxytocin, as well as other hormones like vasopressin, or antidiuretic hormone, which is involved in regulating the amount of water in our body.

When oxytocin is produced, it travels down the axons of these neurons, and reaches the posterior lobe of the pituitary gland.

Down the length of these axons, there are small dilations called Herring bodies – which store the oxytocin until it’s released in the blood.

Outside of pregnancy, oxytocin levels are low, but production increases just a bit during an orgasm - so here’s the reason for that lovely “afterglow”.

Prolactin, on the other hand, is synthesized by special cells called lactotrophs, which are in the anterior lobe of the pituitary.

In women that are not pregnant or breastfeeding, and in men, prolactin levels are usually kept in check by the hypothalamus in two ways.

The first way is the most important, and it’s when the hypothalamus secretes a constant stream of dopamine - which is also called prolactin inhibiting factor.

Dopamine binds to specific receptors on the lactotrophs and inhibits the release of prolactin.

The second way is when the hypothalamus secretes thyrotropin releasing hormone, also called prolactin releasing hormone, which can stimulate prolactin release.