AssessmentsPaget disease of the breast
Paget disease of the breast
USMLE® Step 1 style questions USMLE
USMLE® Step 2 style questions USMLE
A 65-year-old woman comes to the clinic for a breast biopsy of an abnormal lesion noted on mammogram. Her mammogram showed bilateral small nodules within the breast tissue. Physical examination does not show any palpable mass and there are no skin changes or lymphadenopathy. A biopsy of one of these abnormal nodules shows small cells that are arranged in a single line invading the normal breast stroma. The cells do not stain with E-cadherin. Which of the following is the most likely diagnosis?