Penile cancer



Penile cancer

Reproductive system


Penile cancer


0 / 6 complete

USMLE® Step 1 questions

0 / 2 complete

High Yield Notes

7 pages


Penile cancer

of complete


USMLE® Step 1 style questions USMLE

of complete

A 52-year-old man presents to an outpatient clinic for evaluation of an itchy rash on his penis. The rash has been present on the glans of the penis for seven weeks. The patient immigrated from Argentina in his twenties and is unsure of his vaccination status. He has had multiple sexual partners and occasionally uses condoms for protection. Physical examination reveals an uncircumcised penis. A 2-cm velvety, red, well-marginated, painless ulcer is noted on the glans penis. No other penile deformities are observed. Which of the following is the most likely diagnosis?

Memory Anchors and Partner Content

External References

First Aid








Human papillomavirus (HPV)

penile cancer p. 675

Penile cancer p. 224


Penile cancer is a malignant type of cancer that occurs in the tissues of the penis. Risk factors include smoking, uncircumcision, HPV infection, and a weakened immune system. Common symptoms of penile cancer include penile sores, bumps, and warts on the penis; changes in the color or thickness of penile skin; bleeding or discharge from the penis; and painful and difficult urinating. Treatment for penile cancer may include surgery to remove the cancerous tissue, radiation therapy, and chemotherapy.


Copyright © 2023 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.