Phyllodes tumor

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Summary of Phyllodes tumor

A phyllodes tumor is a fibroadenoma-like tumor characterized by an overgrowth of the fibrous component of the breast. These tumors are typically large, fast-growing masses that form from the periductal stromal cells of the breast. They account for less than 1% of all breast neoplasms and most commonly seen in postmenopausal women. They can be malignant in some cases.

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Phyllodes tumor

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Phyllodes tumor

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A 45-year-old woman comes to the office because she is concerned she may have breast cancer. She says that while she was doing her monthly breast examination, she noticed a firm non-tender mass in her left breast. Her past medical history is significant only for hypertension, for which she takes hydralazine. She drinks about a glass of wine or two a week and does not smoke or use illicit drugs. Her family history is negative for cancer. Physical examination shows a mobile, multinodular tumor in the left lower quadrant of the breast that measures about 5 cm in diameter. The overlying skin appears stretched and non-erythematous. She has no lymphadenopathy. Which of the following is the most likely diagnosis?

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