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Information for patients and families
Glut1 deficiency syndrome (Glut1 Deficiency Foundation)
Gorlin syndrome (Gorlin Syndrome Alliance)
Recurrent pericarditis (NORD)
Autoimmune polyglandular syndrome type 1 (NORD)
Opsoclonus myoclonus syndrome (NORD)
Thyroid eye disease (NORD)
Bile synthesis disorders (NORD)
Cyclic vomiting syndrome (NORD)
Eosinophilic esophagitis (NORD)
Short bowel syndrome (NORD)
Essential thrombocythemia (NORD)
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Sickle cell disease (NORD)
Waldenstrom macroglobulinemia (NORD)
Warm autoimmune hemolytic anemia and cold agglutinin (NORD)
Congenital athymia (NORD)
Cytomegalovirus infection after transplant (NORD)
Post-transplant lymphoproliferative disorders (NORD)
Severe chronic neutropenia (NORD)
Alagille syndrome (NORD)
Aromatic L-amino acid decarboxylase deficiency (NORD)
Cerebrotendinous xanthomatosis (NORD)
Classical homocystinuria (NORD)
Congenital cytomegalovirus (NORD)
Fabry disease (NORD)
Gaucher disease (NORD)
Glycogen storage disease type II (NORD)
Metachromatic leukodystrophy (NORD)
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Mycobacterium avium complex (NORD)
NGLY1 deficiency (NORD)
Niemann-Pick disease types A and B (NORD)
PIK3CA-related overgrowth spectrum (NORD)
Tay-Sachs disease (NORD)
Zellweger spectrum disorders (NORD)
Early infantile epileptic encephalopathy (NORD)
Opsoclonus myoclonus syndrome (NORD)
Spinocerebellar ataxia (NORD)
Focal segmental glomerulosclerosis (NORD)
IgA nephropathy (NORD)
Pulmonary arterial hypertension (NORD)
ADHD: Information for patients and families (The Primary School)
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Childhood nutrition and obesity: Information for patients and families (The Primary School)
Childhood oral health: Information for patients and families (The Primary School)
Food allergies and EpiPens: Information for patients and families (The Primary School)
Toxic stress: Information for patients and families (The Primary School)
Posttransplant lymphoproliferative disorders, or PTLDs, are uncontrolled growths of cells called lymphocytes that may occur in transplant recipients after receiving a solid organ, such as a kidney or a lung, or stem cells.
Transplant recipients require medications to suppress their immune systems which may contribute to the development of a PTLD.
Normally, immune cells can differentiate between healthy “self” and “other” cells by inspecting for the presence or absence of the normal “self” major histocompatibility complexes, also called human leukocyte antigens, present on the surface of every cell that contains a nucleus.
Healthy “self” cells are left alone.
“Others” include cells from other people or donors and “self” cells that are infected, damaged, or stressed.
Lymphocytes, are a class of rapidly dividing cells and, therefore, tends to develop mutations more often.
Cytotoxic T-cells can directly destroy “other” cells and helper T-cells assist other immune cells.
Resulting uncontrolled growth of lymphocytes can either be a benign hyperplasia, meaning there’s a large collection of noncancerous cells, or the cells can become malignant, resulting in a cancer called lymphoma.
Post-transplant lymphoproliferative disorders (PTLDs) are a group of lymphoid neoplasms characterized by uncontrolled growths of lymphocytes. It occurs after someone has received a solid organ or stem cell transplant that requires immunosuppressive medications to prevent transplant rejection. PTLDs are caused by Epstein-Barr virus (EBV) infection and can originate in either type of lymphocyte: B-cells or T-cells. Diagnosis involves blood tests, a biopsy, and imaging, while treatment may include surgery, chemotherapy, and radiation.
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