Poxvirus (Smallpox and Molluscum contagiosum)

$Chapter 2 Acyanotic Defects NOTES POXVIRIDAE MICROBE OVERVIEW Genetic material ▪ Linear double-stranded DNA Replication ▪ In host cell cytoplasm Taxonomy ▪ Poxviridae: family of double-stranded DNA viruses Associated clinical syndromes ▪ Febrile rash illnesses: smallpox (eradicated), monkeypox ▪ Skin lesions: vesicles, pustules, papules, skin thickening Morphology ▪ Brick-shaped/ovoid ▪ Enveloped (outer lipid membrane) ▪ Size: 220–450nm MOLLUSCUM CONTAGIOSUM osms.it/molluscum-contagiosum PATHOLOGY & CAUSES ▪ Molluscum contagiosum virus (MCV): poxvirus; causes papular skin disease ▪ Four subtypes; genotype 1 causes most U.S. cases ▪ Common in children, adolescents ▪ Skin penetration → stratum spinosum replication within keratinocytes → epidermal hypertrophy → papules ▪ Incubation period: 2–6 weeks COMPLICATIONS ▪ Widespread/refractory lesions in immunosuppressed individuals CAUSES ▪ Physical contact, autoinoculation, fomites RISK FACTORS ▪ Contact sports; sexual intercourse with infected individuals; immunosuppression; atopic dermatitis Figure 91.1 The wart-like lesions caused by molluscum contagiosum infection. OSMOSIS.ORG 497$

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Poxvirus (Smallpox and Molluscum contagiosum)

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Poxvirus (Smallpox and Molluscum contagiosum)

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