A 22-year-old man presents to the emergency department for evaluation of
penile pain of six hours duration. Past medical history is significant for
sickle cell disease. He does not use illicit drugs or take any medications daily. Temperature is 37.0°C (98.6°F),
pulse is 94/min, and
blood pressure is 125/80 mmHg. Physical examination demonstrates an engorged
penis that is painful with manipulation. No
urethral discharge is noted. The
testicles are nontender, and the cremasteric reflex is intact. Which of the following best describes the underlying pathophysiology of this patient’s condition?
