AssessmentsPrimary biliary cirrhosis
Primary biliary cirrhosis
In primary biliary cholangitis, jaundice occurs when most of the have been destroyed.
USMLE® Step 1 style questions USMLE
A 66-year-old woman comes to the clinic because of hypopigmentation of her hands and skin for several years as well as fatigue and steatorrhea. Examination shows xanthoma and hepatosplenomegaly in addition to peripheral hypopigmentation. Liver function tests show increased GGT and ALP concentrations. Anti-mitochondrial antibodies are present. A recent bone densitometry shows a T-score consistent with osteoporosis. Which of the following is the most likely diagnosis?