AssessmentsProtein C deficiency
USMLE® Step 2 style questions USMLE
A 31-year-old woman is hospitalized after experiencing a pulmonary embolism. She is started on warfarin therapy. 3 days later, she begins to develop well-demarcated areas of ecchymosis, necrosis, and painful, fluid-filled bullae on her extremities, breasts, and trunk. Serum laboratory studies show a deficiency in a protein that normally inactivates clotting factors V and VIII. Which of the following is the most appropriate acute management of this patient?