Protein losing enteropathy
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Protein losing enteropathy
Pathology
Congenital disorders
Disorders of the liver and biliary system
Disorders of the oral cavity, salivary glands, and esophagus
Disorders of the pancreas
Disorders of the peritoneal cavity
Disorders of the stomach, small intestine, colon, rectum, and anus
Infectious, immunologic, and inflammatory disorders
Neoplasms
Traumatic and mechanical disorders
Gastrointestinal system pathology review
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Protein losing enteropathy
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Summary
Protein-losing enteropathy (PLE) refers to any condition of the gastrointestinal tract, such as damage to the gut wall, that results in a net loss of protein from the body. PLE can be caused by conditions like inflammatory bowel disease, celiac disease, lymphangiectasia, and certain types of cancer.
Symptoms of PLE can include diarrhea, abdominal pain, weight loss, and edema due to the loss of protein from the body. In addition, PLE can lead to a decrease in the level of proteins in the blood (hypoproteinemia) which can lead to anemia, a decrease in immunity, and an increase in the risk of infections. Treatment of PLE focuses on correcting the underlying disease and may include medications to reduce inflammation, surgery, protein, as well as vitamin and mineral supplements to prevent malnutrition.