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psoriatic arthritis p. 479
HLA-B25 and p. 98
leflunomide for p. 499
psoriasis and p. 489
Psoriatic arthritis is also one disease in a group of diseases called seronegative spondyloarthropathies.
Spondyloarthropathies are autoimmune diseases that affect the joints, and they’re seronegative, meaning that there aren’t any specific autoantibodies linked to them.
Normally, immune cells are ready to spot and destroy anything foreign that could cause the body harm.
This MHC class I molecule acts like a serving platter, presenting molecules from within the cell for the immune system to sample.
Normally, the antigen that’s presented is from the cell, and the immune system recognizes it as a harmless self-antigen, which leads to no response.
In these individuals, the immune system attacks self-antigens specifically ones in the joints.
Exactly what causes this is unclear, but it's clear that the gene is not enough to trigger psoriatic arthritis.
Psoriatic arthritis is a type of inflammatory arthritis that will develop in some people with the chronic skin condition psoriasis. Psoriatic arthritis typically affects the joints of the fingers and toes, as well as the spine, hips, and knees, causing joint pain, swelling, and stiffness. Treatment includes NSAIDs, sulfasalazine, and methotrexate.
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