Psoriatic arthritis
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Psoriatic arthritis
Musculoskeletal system
Pediatric musculoskeletal conditions
Radial head subluxation (Nursemaid elbow)
Developmental dysplasia of the hip
Legg-Calve-Perthes disease
Slipped capital femoral epiphysis
Transient synovitis
Osgood-Schlatter disease (traction apophysitis)
Musculoskeletal injuries and trauma
Rotator cuff tear
Dislocated shoulder
Radial head subluxation (Nursemaid elbow)
Winged scapula
Thoracic outlet syndrome
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Ulnar claw
Erb-Duchenne palsy
Klumpke paralysis
Iliotibial band syndrome
Unhappy triad
Anterior cruciate ligament injury
Patellar tendon rupture
Meniscus tear
Patellofemoral pain syndrome
Sprained ankle
Achilles tendon rupture
Spondylolysis
Spondylolisthesis
Degenerative disc disease
Spinal disc herniation
Sciatica
Compartment syndrome
Rhabdomyolysis
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Lordosis, kyphosis, and scoliosis
Joint disorders
Osteoarthritis
Spondylosis
Spinal stenosis
Rheumatoid arthritis
Juvenile idiopathic arthritis
Gout
Calcium pyrophosphate deposition disease (pseudogout)
Psoriatic arthritis
Ankylosing spondylitis
Reactive arthritis
Spondylitis
Septic arthritis
Bursitis
Baker cyst
Muscular disorders
Muscular dystrophy
Polymyositis
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Musculoskeletal system pathology review
Back pain: Pathology review
Rheumatoid arthritis and osteoarthritis: Pathology review
Seronegative and septic arthritis: Pathology review
Gout and pseudogout: Pathology review
Systemic lupus erythematosus (SLE): Pathology review
Scleroderma: Pathology review
Sjogren syndrome: Pathology review
Bone disorders: Pathology review
Bone tumors: Pathology review
Myalgias and myositis: Pathology review
Neuromuscular junction disorders: Pathology review
Muscular dystrophies and mitochondrial myopathies: Pathology review
Assessments
Psoriatic arthritis
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0 / 9 complete
USMLE® Step 1 questions
0 / 2 complete
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15 pages
Flashcards
Psoriatic arthritis
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Questions
USMLE® Step 1 style questions USMLE
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Retrieved fromWikimedia Commons
Which of the following clinical findings is associated with this patient’s condition?
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First Aid
2022
2021
2020
2019
2018
2017
2016
Patches (skin)
psoriatic arthritis p. 479
Psoriatic arthritis p. 479
HLA-B25 and p. 98
leflunomide for p. 499
psoriasis and p. 489
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Transcript
Content Reviewers
Rishi Desai, MD, MPHIn psoriatic arthritis, arthritis means joint inflammation, and psoriatic refers to psoriasis, which is an autoimmune disease characterized by red scaly patches in the skin.
So psoriatic arthritis is a type of joint inflammation that happens in individuals with psoriasis.
Psoriatic arthritis is also one disease in a group of diseases called seronegative spondyloarthropathies.
Spondyloarthropathies are autoimmune diseases that affect the joints, and they’re seronegative, meaning that there aren’t any specific autoantibodies linked to them.
Normally, immune cells are ready to spot and destroy anything foreign that could cause the body harm.
To help with this, most cells express the gene HLA-B27, which encodes a protein that forms a major histocompatibility complex, or MHC, class I molecule that sits on the surface of the cell membrane.
This MHC class I molecule acts like a serving platter, presenting molecules from within the cell for the immune system to sample.
A CD8+ T-cell, also called a cytotoxic T-cell, uses its T-cell receptor to bind to the antigen presented by the MHC class I molecule.
Normally, the antigen that’s presented is from the cell, and the immune system recognizes it as a harmless self-antigen, which leads to no response.
Now, many individuals with psoriatic arthritis have a specific version of the gene HLA-B27, which somehow leads to an autoimmune process.
In these individuals, the immune system attacks self-antigens specifically ones in the joints.
Exactly what causes this is unclear, but it's clear that the gene is not enough to trigger psoriatic arthritis.
Summary
Psoriatic arthritis is a type of inflammatory arthritis that will develop in some people with the chronic skin condition psoriasis. Psoriatic arthritis typically affects the joints of the fingers and toes, as well as the spine, hips, and knees, causing joint pain, swelling, and stiffness. Treatment includes NSAIDs, sulfasalazine, and methotrexate.
Sources
- "Robbins Basic Pathology" Elsevier (2017)
- "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
- "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
- "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
- "Psoriatic arthritis: from pathogenesis to therapy" Arthritis Research & Therapy (2009)
- "Pathogenetic Overview of Psoriatic Disease" The Journal of Rheumatology Supplement (2012)
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