Renal papillary necrosis
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Renal system
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Renal papillary necrosis
USMLE® Step 1 style questions USMLE
A 50-year-old man comes to his primary care physician’s office for routine follow-up. He was recently diagnosed with osteoarthritis of the knees four weeks ago and was initiated on analgesic medications. Past medical history is significant for diabetes mellitus. Current medications include metformin, naproxen and acetaminophen. His vitals and physical exam are within normal limits. Laboratory results are as follows.
Laboratory value | Results | |
4 weeks ago | Today | |
Serum chemistry | ||
Sodium | 138 mEq/L | 137 mEq/L |
Potassium | 4 mEq/L | 4.1 mEq/L |
Bicarbonate | 24 mEq/L | 25 mEq/L |
Chloride | 96 mEq/L | 94 mEq/L |
Creatinine | 1.1 mg/dL | 1.6 mg/dL |
Urinalysis | ||
Protein | 100 mg/day | 102 mg/day |
Cast | None | None |
Blood | negative | negative |
Changes to which of the following anatomic regions is most likely accountable for this patient’s rise in creatinine?
Renal papillary necrosis exam links
Renal papillary necrosis is a condition in which impaired blood supply to the kidneys leads to diffuse ischemia and subsequent necrosis of the renal papilla. Risk factors for renal papillary necrosis include diabetes, sickle cell anemia, and certain medications such as non-steroidal anti-inflammatory drugs (NSAIDs). Symptoms may include fever, flank pain, and blood in the urine. Treatment may include antibiotics, pain management, and in severe cases, surgery.