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Renal tubular acidosis



Renal system


Renal and ureteral disorders
Bladder and urethral disorders
Renal system pathology review

Renal tubular acidosis


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Renal tubular acidosis

14 flashcards

USMLE® Step 1 style questions USMLE

3 questions

A 76-year-old woman presents to the emergency department with fatigue, decreased appetite, and muscle weakness. Past medical history includes chronic migraines, hypertension, gastroesophageal reflux, and a recent episode of podagra. Current medications include topiramate, lisinopril, acetazolamide, omeprazole, and probenecid. Temperature is 37.0°C (98.6°F), pulse is 104/min, respirations are 24/min, and blood pressure is 96/66 mmHg. Arterial blood gas and laboratory testing are obtained, and the results are shown below.

Which of the following medications most likely contributed to this patient’s disease?

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Content Reviewers:

Rishi Desai, MD, MPH

With renal tubular acidosis, renal refers to the kidney, tubular refers to the main tube-portion of the nephron, and acidosis refers to having too many protons or increased acidity in blood, so renal tubular acidosis or RTA describes increased acidity in the blood because the renal tubules can’t get rid of protons.

The kidneys contain millions of nephrons, each of which has a renal corpuscle, and a renal tubule that ends in a collecting duct.

The renal corpuscle filters large amounts of solutes that go from the blood into the filtrate and eventually the urine, and the renal tubule and collecting duct are responsible for fine tuning the reabsorption and secretion of solutes to adjust the amount that ultimately gets retained by or removed from the body.

Broadly speaking, renal tubular acidosis can develop in either the proximal convoluted tubule, sometimes called just the proximal tubule, or the distal convoluted tubule, or distal tubule, and the nearby collecting duct.

The proximal tubule is lined by brush border cells which have two surfaces. One is the apical surface that faces the tubular lumen and is lined with microvilli, which are tiny little projections that increase the cell’s surface area to help with solute reabsorption.

The other is the basolateral surface, which faces the peritubular capillaries, which run alongside the nephron.

Now - when a molecule of bicarbonate approaches the apical surface of the brush border cell it binds to hydrogen to form carbonic acid.

At that point, an enzyme called carbonic anhydrase type 4 which lurks in tubule among the microvilli like a shark, swims along and splits the carbonic acid into water and carbon dioxide. The overall equation looks like this:

H+ + HCO3- <-> H2CO3 <-> H2O + CO2

The water and carbon dioxide happily diffuse across the membrane into the cells where carbonic anhydrase type 2 facilitates the reverse reaction - combining them to form carbonic acid, which dissolves into bicarbonate and hydrogen.

A sodium bicarbonate cotransporter on the basolateral surface snatches up the bicarbonate and a nearby sodium, and shuttles both into the blood.

Meanwhile, a sodium-hydrogen exchanger on the apical surface, pulls sodium into the cell, while pushing hydrogen back into the tubule. So at the end of the day, there’s a movement of bicarbonate from the tubule to the blood.

Okay - so now let’s shift over to the distal tubule and collecting duct which we’ll talk about together. First off, one type of cell these are lined with are the alpha-intercalated cells.

Like the brush border cells, the alpha intercalated cells move bicarbonate and hydrogen from the tubule into the cell using carbonic anhydrase.

The alpha intercalated cells have two major ways to get rid of that hydrogen across the apical surface. First, they have a H+/ATPas e which simply pushes hydrogen into the tubule.

Second, they have a hydrogen potassium ATPase (H+K+ATPase) which pushes hydrogen into the tubule in exchange for potassium.

With regard to bicarbonate, there is a bicarbonate/chloride antiporter which moves bicarbonate into the blood in exchange for chloride. To prevent chloride from piling up within the cell, there’s a potassium/chloride symporter on the basolateral surface that moves both of these ions into the blood.In addition, there’s a chloride channel on the basolateral surface that allows chloride to passively move down its concentration gradient into the blood.

Finally, it’s worth mentioning that like all cells - sodium and potassium levels are controlled by Na/K ATPase pumps on the basolateral surface which move two potassium ions into the cell and three sodium ions out of the cell. So overall, there’s a net movement of sodium, chloride, and bicarbonate into the blood, while hydrogen is pushed into the tubule.

Once in the lumen, hydrogen binds to phosphate or ammonia to form relatively weak acids like dihydrogen phosphate or ammonium, which then get peed out in the urine. This allows protons to get removed without making the urine too acidic and damaging the cells lining the tubules and the rest of the urinary tract.

The other group of cells are the principal cells.These cells have two channels on the apical surface, a potassium channel the allows potassium into the lumen and an epithelial sodium channel called ENaC that allows sodium into the cell.

The flow of positively charged sodium ions into cell helps drive the positively charged potassium ions out of the cell against their concentration gradient.

There’s also a Na/K ATPase pump on the basolateral surface that again moves 2 potassium ions in for every 3 sodium ions out.

All three of these are stimulated by aldosterone, and the combined effect is resorption of sodium and loss of potassium.

In RTA type I or distal renal tubular acidosis, the main issue is that alpha intercalated cells of the distal tubule and collecting duct are unable to secrete hydrogen. The buildup of hydrogen in those cells leads to a buildup of hydrogen in the blood - resulting in acidemia.

The underlying cause could be a genetic mutation in the H+ATPase pump or the H+K+ATPase pump of alpha intercalated cells.

Alternatively it could be due to an acquired defect from a medication like lithium or amphotericin B, both of which can make cells permeable, allowing hydrogen to simply diffuse from the tubule right back into the cell.


Renal tubular acidosis is a medical condition in which the kidney is unable to secrete acids or reabsorb bicarbonate from the body. When blood is filtered by the kidney, the filtrate passes through the tubules of the nephron, allowing for the exchange of salts, acid equivalents, and other solutes before it drains into the bladder as urine. The metabolic acidosis that results from renal tubular acidosis may be caused either by failure to recover sufficient bicarbonate ions from the filtrate in the proximal tubule or by insufficient secretion of hydrogen ions into the distal tubule. If left untreated, acidemia can cause peripheral vasodilation and shock. Treatment may include alkali supplements like potassium citrate or sodium bicarbonate to neutralize the acid in the blood.