Toxic doses of cause respiratory alkalosis early, but transitions to mixed metabolic acidosis-respiratory alkalosis.
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A 15-year-old boy comes to the emergency department with his mother because of rapid, uncontrollable breathing. His mother states that two hours earlier the boy's girlfriend ended their relationship. The boy had been sobbing profusely when he started breathing rapidly. The patient states that his mouth feels tingly. His temperature is 37.1°C (98.8°F), pulse is 96/min, respirations are 32/min, and blood pressure is 122/86 mm Hg. Physical examination shows perioral pallor and carpopedal spasm. Which of the following is the most likely etiology of his symptoms?
Content Reviewers:Rishi Desai, MD, MPH
With respiratory alkalosis, “alkalosis” refers to a process that raises blood pH above 7.45, and “respiratory” refers to the fact that it’s a failure of the respiratory system carrying out its normal pH- balancing job.
Normally, during an inhalation, the diaphragm and chest wall muscles contract to pull open the chest and that sucks in air like a vacuum cleaner. Then, during an exhalation, the muscles relax, allowing the elastin in the lungs to recoil, pulling the lungs back to their normal size and pushing that air out.
Ultimately, the lungs need to pull oxygen into the body and get rid of carbon dioxide CO2.
CO2 binds to water H2O in the blood and forms H2CO3 carbonic acid, which then dissociates into hydrogen H+ and bicarbonate ions HCO3-. So, in order to prevent pH fluctuations, the CO2 concentration, or the partial pressure of CO2, called PCO2, needs to be kept within a fairly narrow range.For this reason, lungs maintain the ventilation rate they need to get rid of CO2 at the same rate that it’s created by the tissues.
If PCO2 levels start to fall and pH starts to rise, peripheral chemoreceptors that are located in the walls of the carotid arteries and in the wall of the aortic arch start to fire less, and that notifies the respiratory centers in the brainstem that they need to decrease the respiratory rate and depth of breathing.
As the respiratory rate decreases and breaths become more shallow, the minute ventilation decreases - that’s the volume of air that moves in and out of the lungs in a minute.
The decreased ventilation, means less carbon dioxide CO2 moves out of the body, increasing the PCO2 in the body, which lowers the pH.
In respiratory alkalosis, the normal mechanism of ventilation gets disturbed, and the minute ventilation goes higher than what’s needed to balance the pH.
For ventilation to increase, the respiratory centers have to start firing more than usual.
This increased firing may be a normal compensatory response, or an abnormal response to a situation that doesn’t really call for increased ventilation.
Increased ventilation is a normal response to things like hypoxia, a low oxygen level, which can happen with diseases like pneumonia or a pulmonary embolism, or even when a person climbs a high mountain like Mount Everest.
But, increased ventilation can be an abnormal response that sometimes happens in situations like anxiety and panic attacks, in sepsis, or in overdoses with salicylates.
Rarely, brainstem disorders can irritate the respiratory centers and make them fire more.
Sometimes, increased minute ventilation is iatrogenic, meaning that it’s a result of a medical intervention. For example, a person may be intubated and on a ventilator. If the ventilator settings aren’t correct, it can cause a respiratory alkalosis.
In all of these situations, the result is that lungs get rid of too much CO2.