Restless legs syndrome



Restless legs syndrome



Restless legs syndrome


0 / 5 complete

USMLE® Step 1 questions

0 / 1 complete

High Yield Notes

10 pages


Restless legs syndrome

of complete


USMLE® Step 1 style questions USMLE

of complete

A 50-year-old woman comes to the clinic due to sleeping disturbances for the past 2 months. The patient reports an uncomfortable sensation of the legs that occurs especially at night or during prolonged inactivity. She describes the sensation as a “crawling” and “tingling” sensation which makes her wake up multiple times throughout the night. After waking up, walking and moving her legs provides temporary relief. Medical history is significant for hypertension and diabetes mellitus type 2. The patient’s most recent HbA1C was 7.0% one month ago. Vitals are within normal limits. Physical examination shows bilateral flat foot, for which she uses orthoses. Monofilament examination of the foot is within normal limits. Achilles reflex is 2+ bilaterally. Which of the following is the most likely diagnosis?  


Restless legs syndrome, also known as Willis-Ekbom disease, is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations. It is often bilateral and most commonly affects the legs, but can affect the arms, torso, head, and even phantom limbs. Moving the affected body part modulates the sensations, providing temporary relief. The exact cause of RLS is not known, but it is believed to be related to a dysfunction of the brain's dopamine system. RLS can be treated with medications like dopamine agonists and benzodiazepines; and lifestyle changes, such as avoiding aggravating factors like caffeine intake.


Copyright © 2023 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.