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Rheumatic heart disease



Immune system


General infections
Hypersensitivity reactions
Immune system organ disorders
Immune system pathology review

Rheumatic heart disease


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High Yield Notes
10 pages

Rheumatic heart disease

25 flashcards

USMLE® Step 1 style questions USMLE

4 questions

A 70-year-old man comes to the emergency department for evaluation of dyspnea, dizziness, and associated chest pain. He became more concerned when he was walking up stairs and suddenly “passed out.” His medical history includes type 2 diabetes mellitus, for which he takes metformin. He smoked one pack per day for forty years but does not use excessive alcohol or illicit drugs. His temperature is 37.0°C (98.6°F), pulse is 80/min, and blood pressure is 139/75 mmHg. On physical examination, a systolic murmur is appreciated over the right sternal border, which decreases with sustained hand grip. Which of the following is the most likely underlying cause of this patient's condition? 

External References

“Rheumatism” is used to describe inflammation in the joints, muscles, and the fibrous tissue, so rheumatic fever is a type of inflammatory disease that can damage the heart tissue, and lead to rheumatic heart disease.

Rheumatic fever develops after streptococcal pharyngitis, inflammation of the throat due to Streptococcus pyogenes where pyogenes literally means “makes pus”. The bacteria is sometimes referred to as “Group A beta hemolytic” streptococcus, and the infection itself is most often just called Strep throat. This particular group of streptococcus has an antigen that lumps it into a group called “group A”, and it also produces an enzyme called streptolysin, that completely lyses nearby red blood cells, or causes them to rupture—rupturing red blood cells is called hemolysis, right? And when those red blood cells rupture and are destroyed, it’s called beta-hemolysis—as opposed to alpha-hemolysis, where cells aren’t actually destroyed, they’re just damaged or bruised.

Some of these strep bacteria have a protein on their cell wall called “M protein”, and this particular protein is highly antigenic, meaning that the immune system sees it and recognizes it as a foreign molecule, and mounts an immune response, which rightfully so, produces antibodies against these proteins. Those antibodies, though, are thought to cross-react with proteins on some of our body’s own cells, like cells in the myocardium (or heart muscle) and heart valves, but also cells in the joints, the skin and the brain.

This phenomenon, where antibodies accidentally target proteins on our own cells because they look like the proteins on foreign cells, is called molecular mimicry, and is an example of what’s called a type 2 hypersensitivity reaction. Once bound to cardiac tissue, the antibodies activate nearby immune cells, which causes a cytokine-mediated inflammatory response and tissue destruction.

Obviously though, not everyone that gets strep throat gets rheumatic fever, right? And it’s actually only a small minority that get it, estimated around 3%, and it’s more likely to happen in children or people in areas of poverty and crowding.

A lot of patients that do get rheumatic fever from strep, sometimes called acute rheumatic fever, will have a variety of clinical findings. The most common of which is migratory polyarthritis of the joints—where multiple large joints become inflamed, swollen and painful, one after another, although this damage isn’t permanent.

Secondly, some patients have pancarditis, or inflammation of all three layers of the heart tissue. The first, endocarditis, is inflammation of the inner lining which includes the valves. The mitral valve is most commonly affected, although the aortic valve might also be affected.

The next is myocarditis, inflammation of the myocardium, or heart muscle. Inflamed areas in the myocardial tissue are called Aschoff bodies, which are areas of fibrinoid necrosis, with immune cells like T cells and these characteristic Anitschkow cells, enlarged macrophages which have characteristic caterpillar-looking nuclei.

It turns out that myocarditis is the most common cause of death in acute rheumatic fever because this inflammation and necrosis makes the heart wall unable to contract with full force, which results in heart failure.

Finally there’s pericarditis, or inflammation of the outer covering of the heart called the pericardium, which can cause pain as well as a friction rub from the inflamed visceral pericardium rubbing against the inflamed parietal pericardium- which can actually be heard with a stethoscope.

In addition to joint and heart problems, the hypersensitivity reaction in rheumatic fever can affect other tissues as well. Patients can develop subcutaneous nodules, these firm lumps under the skin made up of collagen. They might also have erythema marginatum, this reddish rash that shows up as rings on the arms or trunk. Also, they could have Sydenham’s chorea, which is a set of rapid movements of the face and the arms, from an autoimmune reaction against the basal ganglia of the brain, and this one typically won’t appear until late in the disease, at least 3 months after infection.


Rheumatic heart disease is a condition that develops as a complication of rheumatic fever, which is an inflammatory disease that can occur as a complication of streptococcal infections such as strep throat. This occurs due to the antibodies against streptococcal M proteins that cross-react with proteins in the myocardium, heart valves, joints, skin, and brain.

Rheumatic heart disease is characterized by heart tissue scarring that damages the heart valves, leading to problems such as mitral stenosis, and aortic regurgitation. Symptoms of rheumatic heart disease include shortness of breath, fatigue, chest pain, and heart palpitations. Treatment may involve antibiotics to prevent further streptococcal infections, and surgery to repair or replace damaged heart valves.

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  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
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  5. "Rheumatic fever & rheumatic heart disease: the last 50 years" Indian J Med Res (2013)
  6. "Rheumatic heart disease" The Lancet (2012)
  7. "Rheumatic Heart Disease: Causes, Symptoms, and Treatments" Cell Biochemistry and Biophysics (2015)