00:00 / 00:00
0 / 13 complete
0 / 2 complete
rotavirus p. 165
rotavirus p. 165
diarrhea p. 164
rotavirus p. 164
In fact, it’s believed that almost every child has had the vaccine or been infected by this virus at least once before the age of five.
This tells us that this family of viruses affect either the respiratory system, the intestines, or they’re “orphans” who don’t cause any disease, as far as we can tell.
They are surrounded by a double icosahedral capsid, which is a two-layered spherical protein shell made up of 20 equilateral triangular faces.
And they’re “naked” because the capsid isn’t covered by a lipid membrane.
They’re RNA viruses with double stranded linear RNA with 10 to 12 segments.
This means that they must first transcribe their genetic material into single stranded mRNA before host cell ribosomes can use it to make viral proteins.
Transcription happens inside the capsid, using a viral enzyme called RNA-dependent RNA polymerase.
Then the mRNA enters the host cell’s cytoplasm where ribosomes are found.
Rotavirus is transmitted from person to person via the fecal-oral route.
In other words, you catch it by ingesting the stool or vomit particles of someone who is sick. Yuck.
This can happen if infected stool ends up in the water supply or on agricultural fields, if flies land on it, and transfers stool particles to other places, or by touching contaminated surfaces.
You can summarize it as the four Fs: fluids, fields, flies, and fingers.
And in turn, each villus is covered in teeny tiny little microvilli. This is called the brush border.
All of this gives the small intestines plenty of surface area to absorb nutrients.
Rotavirus is a double-stranded RNA virus from the reovirus family. It's a contagious virus transmitted via the fecal-oral route, and is known to cause severe viral gastroenteritis especially in children. It mainly affects the small intestine and causes symptoms like acute onset vomiting, watery diarrhea, abdominal pain, and fever, and severe cases can be fatal. A vaccine is available to prevent rotavirus infection. Good hygiene practices, such as washing hands with soap and water can also help prevent its spread.
Copyright © 2023 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Cookies are used by this site.
USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.