Rubella virus

14,487views

00:00 / 00:00

High Yield Notes

5 pages

Flashcards

Rubella virus

de completadas

Preguntas

Preguntas del estilo USMLE Step 1

de completadas

A 1 month-old girl is brought to the clinic for a routine evaluation. The patient was delivered via a cesarean at 38-weeks gestational age due to arrested labor. The mother immigrated from Zambia ten months ago and received minimal prenatal care. During the first trimester of pregnancy, she developed an upper respiratory infection and self-limited joint pain affecting the wrists, knees, and ankles. Family history is notable for retinitis pigmentosa. The patient’s weight is at the 20th percentile, and head circumference is at the 50th percentile. Vitals are within normal limits. She does not move her head in response to sounds. Facial features appear normal. Physical examination is notable for petechiae and purpura over the arms, trunk, and legs. A cardiac examination reveals a continuous murmur heard in the left infraclavicular area. Abdominal examination is notable for hepatosplenomegaly. Which of the following findings is most likely present on this patient’s ophthalmologic examination?  

External References

First Aid

2024

2023

2022

2021

Rubella p. 166

cardiac defect association p. 304

cataracts p. 550

heart murmur with p. 296

rash p. 178

ToRCHeS infection p. 181

unvaccinated children p. 183

Lymphadenopathy

rubella p. 166, 181, 178

Cataracts p. 550

rubella p. 181

Congenital heart disease p. 302-304

rubella p. 181

Deafness

rubella p. 181

Blueberry muffin rash

rubella p. 166, 181

Polyarthralgias

rubella p. 181

Polyarthritis

rubella p. 181

Rashes

rubella p. 166, 178

Arthralgias

rubella p. 166, 181

Togaviruses

rubella as p. 164

Enlaces externos

Transcript

Watch video only

Content Reviewers

Contributors

Rubella, the infection formerly known as “German Measles,'' is caused by the Rubella virus.

Thanks to vaccination, it’s a disease we see less and less, although because some groups are under-immunized, it’s still possible to see outbreaks.

The Rubella virus is part of the Togaviridae family.

Togaviruses are single-strand RNA viruses surrounded by an icosahedral capsid, which is a spherical protein shell made up of 20 equilateral triangular faces, all within a spherical outer lipid envelope.

They’re also positive sense RNA viruses, which means that their genetic material is actually mRNA, so it can be used right away by the host cell to make viral proteins.

Now, the Rubella virus is transmitted through respiratory droplets, which are released into the environment when you sneeze or cough on another person.

Within the nasopharynx mucous membrane, the virus binds to a specific receptor on the membrane of epithelial cells.

It’s then surrounded by a little section of cell membrane that pinches off to form an endosome, that’s brought into the cell.

The low pH in the endosome uncoats the viral RNA and the virus causes changes to the endosome.

Now, when the Rubella virus enters the cell it also rearranges some of the organelles, gathering the endoplasmic reticulum, golgi apparatus, and mitochondria around the endosome.

The result is a membrane-bound Viral Replication Complex where - like the name says - the virus replicates.

So, after the virus replicates, its structural proteins are synthesized using the rough endoplasmic reticulum and these proteins are then transported to the golgi apparatus to be assembled and surrounded by membrane, a process called viral budding.

The new virus copy eventually exits the cell by exocytosis and enters nearby lymphatic and blood vessels, travelling to lymph nodes where it will replicate once again.

From the lymph nodes, it enters blood vessels again, and spreads to various parts of the body, making its way into various bodily fluids like urine, cerebrospinal fluid, and synovial fluid of joints.

Finally, the Rubella virus has a cytopathic, or cell-damaging, effect, that’s linked to viral replication.

Resumen

Rubella virus is a single-strand, positive-sense RNA virus of the Togaviruses family, which is known to cause rubella, sometimes referred to as German measles. The virus is spread through respiratory droplets and infects and replicates in mucous membrane cells of the nasopharynx, then does the same in lymph nodes, triggering apoptosis in infected cells. Infected children are often asymptomatic or might have mild symptoms like fever, lymphadenopathy, and a rash, whereas adults tend to show more serious symptoms and get sick longer. Complications of rubella are rare but may include arthritis, encephalitis, and thrombocytopenia. Treatment for Rubella is supportive and prevention involves a live attenuated vaccine.

Elsevier

Copyright © 2024 Elsevier, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.

RELX