USMLE® Step 1 style questions USMLE
A 40-year-old man comes to the office because of pain in the right lower back with radiation down the back of the right leg into the foot. He says this started a few weeks ago and has progressively worsened. He denies any previous trauma. His past medical history is significant for hypertension which was diagnosed at his last visit two months ago and is well-controlled on hydrochlorothiazide. Physical examination shows the patient does not have point tenderness in the vertebrae or in the right hip. He has minimally decreased sensation along the back of the right thigh. Muscle strength is 5/5 and symmetric. Which of the following is the most likely cause of his symptoms?
Sciatica is a condition where there’s pain that starts in the lower back and goes down the leg.
All the nerves in the plexus, except S3 are split into two divisions: anterior and posterior.
These two nerves are bound together by connective tissue and make up the sciatic nerve.
The sciatic nerve innervates the muscles in the back of the thigh.
L4 covers the medial side of the leg, L5 the lateral side.
S1 covers part of the dorsum and the entire sole of the foot, S2 the back of the leg, while S3 covers the back of the thigh.
Skin sensations like touch, temperature, pain, and pressure are carried to the spinal cord and then to the brain where we register the sensations.
The causes of sciatica can be divided into two groups - spinal, and non-spinal.
Spinal causes are related to the spinal column.
The most common one is intervertebral disc herniation.
Each disk is made of two parts.
The outer fibrous ring called annulus fibrosus, and the inner gel-like pulp - nucleus pulposus.
The inflammation and swelling which result from this reaction compresses the nerves even further.
Another cause of nerve compression is spinal stenosis which is narrowing of the spinal canal or intervertebral foramen.
- "Robbins Basic Pathology" Elsevier (2017)
- "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
- "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
- "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
- "Sciatica" British Journal of Hospital Medicine (2016)
- "Late sciatic nerve entrapment following pelvic plate reconstruction in total hip arthroplasty" The Journal of Arthroplasty (1998)