Seizures: Clinical practice

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Seizures: Clinical practice

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A 20-year-old woman, gravida 1, comes to the neurology clinic during her first trimester because she has been experiencing 15-second periods of unconsciousness that are not followed by a period of lethargy. Her partner says that during these episodes, she appears to stare off into space. Neurological examination is noncontributory, so a brain scan and multiple EEG’s are conducted which suggest she has been experiencing seizures. Which of the following medications is the most appropriate next step in management? 

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Content Reviewers:

Rishi Desai, MD, MPH

A seizure is a paroxysmal motor, sensory or autonomic event that occurs due to abnormal, excessive and synchronous electrical discharges from neurons in the brain, and usually lasts less than 5 minutes.

If a seizure lasts more than 5 minutes, it’s called status epilepticus.

And the term “convulsion”, refers specifically to motor seizures.

Now, a seizure is different from epilepsy.

Epilepsy is a chronic disease of the brain that predisposes an individual to having recurrent unprovoked seizures; that is seizures without a clear triggering cause.

Epilepsy is typically diagnosed when an individual has two or more unprovoked seizures separated by at least twenty-four hours.

Epilepsy can also be diagnosed when an individual has one seizure and a high likelihood of having another one.

There are many different forms and causes of epilepsy.

Seizures are classified into generalized and focal seizures.

Generalized seizures arise from both cerebral hemispheres at the same time, while focal seizures arise from specific areas in one cerebral hemisphere.

Now, generalized seizures are subclassified into motor and non-motor seizures.

Regardless of the subtype, generalized seizures almost always cause a sudden impairment of consciousness.

Generalized motor seizures include tonic, clonic, tonic-clonic, atonic, and myoclonic seizures.

Tonic seizures involve sudden stiffening of the muscles, while clonic seizures involve rhythmic twitching of the muscles. However, these clinical features are usually combined, so individuals commonly have a tonic-clonic seizure.

In a generalized tonic-clonic seizure, a person may have a sudden contraction of their vocal cord muscles, causing them to involuntarily scream or cry during a seizure.

Contraction of the ocular muscles can cause uprolling of the eyes.

Contraction of the oropharyngeal muscles can impair swallowing, causing respiratory secretions to pool in the oropharynx.

Contraction of the jaw muscles may cause the individual to bite on their tongue.

Individuals with tonic-clonic seizures may also develop urinary or fecal incontinence.

After the tonic-clonic seizure ends, individuals enter a period called the post-ictal phase, during which the individual’s consciousness is still impaired for minutes to hours - so they seem sluggish and tired or even hard to wake up. Sometimes, if the seizure event is unwitnessed, the post-ictal phase is the only indication that a seizure even happened, because the affected individual likely won’t remember the event itself.

Alright, now atonic seizures translates to “no muscle tone”. Therefore they are characterized by sudden loss of postural muscle tone lasting 1 to 2 seconds, causing the individual to collapse to the ground out of the blue.

The last of the generalized motor seizures are myoclonic seizures, which involve sudden, rapid, shocklike muscle contractions. This sounds a lot like clonic seizures, but the key difference is that in myoclonic seizures, the contractions are much faster, occurring at a rate of 0.1 seconds, whereas in clonic seizures, the contractions occur at a rate of about 1 to 2 seconds.

Alright, moving on to the other arm of generalized seizures, there are the generalized non-motor seizures. These are called absence seizures and are commonly found in children and adolescents.

The interesting thing about absence seizures is…………………..alright as a quick recap. Just kidding, but what just happened is exactly what individuals with absence seizures experience.

Episodes are characterized by sudden, brief loss of consciousness for seconds to minutes without any change in the individual’s postural muscle tone. So they could be sitting watching an osmosis video and suddenly lose consciousness without falling down, only to wake up at the end of the video.

Unfortunately, episodes can occur dozens or even hundreds of times per day, and are classically described by parents and teachers as “staring into space”, or “daydreaming”, or being “inattentive”.

In fact, many children with absence seizures are actually misdiagnosed with attention-deficit hyperactivity disorder, because teachers often presume that a child is just not paying attention.

Focal seizures are classified into those that do not impair consciousness, previously called simple partial seizures, and those that impair consciousness, previously called complex partial seizures.

Focal seizures that impair consciousness are followed by a post-ictal phase, whereas focal seizures that retain consciousness do not have a postictal phase.

Now, focal seizures can be motor, sensory, or autonomic, depending on the area of the cerebral cortex involved. For example, a focal seizure involving the primary motor cortex may cause tonic or clonic movements of the contralateral extremity, whereas a focal seizure involving the occipital cortex may cause someone to see flashing lights.

Sometimes, focal seizures may begin as subtle neurological symptoms called auras.

During an aura, individuals may exhibit subtle muscle movements called automatisms, such as chewing, lip smacking, or rapid blinking of the eyes. Other interesting forms of aura include smelling unusual odors like kerosene, a rising sensation in abdomen, or even feelings of fear or deja vu.

Also, an interesting phenomenon that occurs after focal motor seizures is Todd’s paralysis, which describes a temporary paralysis of the affected extremity.

Finally, it’s important to note that focal seizures can spread to both cerebral hemispheres, causing a generalized seizure. When this happens, it’s appropriately called secondary generalization of a focal seizure.

Naturally, it might be difficult to know if a seizure was a generalized tonic-clonic right from the beginning, or if it was a focal seizure that secondarily generalized. However, a history of an aura, unilateral shaking, turning of the head to one side or Todd’s paralysis - which is a focal weakness in a part or all of the body after a seizure, is a clue it may have been a focal seizure that secondarily generalized. Take that with a grain of salt though, because the absence of these historical features does not adequately exclude a focal seizure.

Alright, now seizures are just a symptom, much like chest pain or shortness of breath, and therefore the causes of seizures are many.

We can categorize them based on the mnemonic “VITAMINS”. “V” stands for vascular, which includes ischemic or hemorrhagic strokes or intracerebral hemorrhage.

“I” is for infection, which includes meningitis, encephalitis or brain abscess.

“T” is for trauma, especially penetrating traumatic brain injury, such as that from a gunshot.

“T” is also for toxins. This includes drugs of abuse such as cocaine or amphetamine overdose, or alcohol withdrawal, which typically develops 48 hours after the last drink.

Additionally, the anti-tuberculosis medication isoniazid can potentially cause seizures secondary to pyridoxine or vitamin B6 deficiency.

The antidepressant bupropion can also cause seizures, especially if given in individuals with eating disorders like anorexia or bulimia.

“A” is for autoimmune, such as central nervous system vasculitis or lupus.

“M” is for metabolic, and this category includes a bellevue of electrolyte imbalances such as hyponatremia or hypocalcemia, or other metabolic imbalances such hypoglycemia or hyperglycemia, hyperthyroidism, hepatic encephalopathy in liver disease or uremic encephalopathy in kidney disease.

Also, Wernicke encephalopathy caused by thiamine deficiency should be considered, especially in alcoholics.

“I” is for idiopathic, which means epilepsy.

“N” is for neoplasm and “S” is for the differential diagnoses like psychogenic seizures or syncope.

Also, one separate diagnosis that should be specifically considered in pregnant female is eclampsia, which is when a female with preeclampsia develops seizures.

Okay, so when an individual presents with a history of a paroxysmal event, it’s important to first make sure the event was truly a seizure.

The differential diagnoses of a seizure includes syncope, a nonepileptic spell caused by a functional neurological disorder, a transient ischemic attack or TIA, a migraine, and vertigo.

Syncope is usually preceded by a prodrome of lightheadedness or sweating, followed by a brief loss of consciousness lasting seconds.

Similar to seizures, tonic or clonic movements can also be present in syncope.

Psychogenic seizures can occur in anyone but some individuals have a history of trauma or abuse. These spells often include features not seen in seizures including full body convulsions with retained awareness, and pelvic thrusting.

TIAs can last anywhere between 5 to 30 minutes, and usually present with the symptoms of a stroke, such as hemiparesis, hemisensory loss or visual loss.

Similar to seizures, individuals with migraine can also develop an aura, however, episodes usually last hours and may be associated with visual disturbance.

Vertigo can last anywhere from a few minutes to a couple of days, however, symptoms are usually dependent on the position of the individual.

Finally, features like tongue biting, as well as the postictal phase of confusion can be seen in seizures, and are usually absent in the other differential diagnoses. For example, individuals with syncope regain full consciousness and alertness only a few seconds after the event.

Now, if there was a seizure, the next step is to determine if the individual has had prior seizures, which establishes a diagnosis of epilepsy, or if this is a first time they’ve had a seizure.

If the individual was previously diagnosed with epilepsy and is on anti-epileptic medication, then assess for the adequacy of that therapy. This includes asking if the individual is taking their anti-epileptic medication, has changed medication doses, started a new medication which might alter the levels of their anti-epileptic medication, experiencing any side effects, and measuring the serum levels of the medication if possible.

If the serum levels are low, then either increasing the dose of the antiepileptic medication, changing the medication, or adding another medication may make sense. However, if the individual is adequately taking the medication and serum levels are normal, then this should prompt evaluation for other causes of seizures.