Septo-optic dysplasia often leads to hypopituitarism which most commonly manifests as deficiency.
USMLE® Step 1 style questions USMLE
A newborn boy is evaluated in the neonatal intensive care unit (NICU) for vital sign instability, and hypoglycemia and hypothyroidism detected on routine newborn screening labs. The child was born at 39 weeks to a G1P1 15-year-old mother who tearfully admits to drinking alcohol on several occasions during pregnancy. The patient’s temperature is 35.8 C (96.4F), pulse is 145/min, respirations are 17/min and blood pressure is 55/35 mmHg. Days later a brain MRI shows a hypoplastic pituitary gland, absence of the septum pellucidum and agenesis of the corpus callosum confirming the diagnosis of septo-optic dysplasia. Which of the following set of hormone level changes is most likely found in this patient?
TSH= Thyroid Stimulating Hormone
TH= Thyroid Hormone
CRP= Corticotropin-Releasing Peptide
ACTH= Adrenocorticotropic Hormone