Seronegative and septic arthritis: Pathology review

Seronegative and septic arthritis are two different forms of arthritis, each with its causes and symptoms. Seronegative arthritis refers to a type of arthritis in which a person tests negative for rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies, which are markers commonly associated with rheumatoid arthritis. Seronegative arthritis can be caused by a variety of conditions, including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, etc.

Septic arthritis, on the other hand, is a severe form of arthritis, often caused by bacterial infections. The infection can enter the joint through a break in the skin, or from an infection in another part of the body that spreads through the bloodstream. Septic arthritis is a medical emergency and requires prompt treatment with antibiotics to prevent joint damage and systemic spread of the infection.