AssessmentsSex cord-gonadal stromal tumor
Sex cord-gonadal stromal tumor
The term sex cord refers to an embryonic structures that develops into ovarian follicle cells in a woman.
Stromal cells are the connective tissue of any organ.
Each ovary has multiple follicles.
Each follicle is made up of an oocyte, which is the immature egg, surrounded by two types of cells - theca cells and granulosa cells.
Granulosa and theca cells work together to support follicle development.
Luteinizing hormone stimulates theca cells to generate androgens and follicle stimulating hormone stimulates granulosa cells to convert those androgens to estradiol using the enzyme aromatase.
A large increase in estradiol triggers ovulation.
During ovulation, the oocyte pops out of the ovary, causing a bit of damage to the surface.
Fibrocytes detect that damage and differentiate into fibroblasts and lay down collagen to help repair the damage.
If any of those cells starts to divide uncontrollably, it can either form a benign tumor which means that it does not invade nearby tissue or spread to other parts of the body, or it can be a malignant tumor which means that it might do both of those things.
Compared with benign tumor cells, malignant tumor cells have key features like not having a clearly defined border or like a slightly less organized nuclei.
The first main type of sex-cord stromal tumor is a granulosa-theca cell tumors are the most common malignant stromal tumors and they’re associated with middle-aged women.
Under the microscope, these tumors classically develop little fluid pockets scattered throughout the tissue that are called Call-Exner bodies.
The second type of tumors, fibromas, are made of fibroblasts and benign tumors.
Under the microscope, they look like thin needle-like strands with elongated nuclei that are bundled together.
In fact, the clinical triad of a benign ovarian tumor with ascites and a pleural effusion, is better known as Meigs syndrome.
Fibromas can occasionally grow to the size of an orange and can cause a pulling sensation in the groin when it compresses the round ligament of the uterus.