Shigella

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17 pages

Questions

USMLE® Step 1 style questions USMLE

of complete

A 16-year-old boy is brought to urgent care for evaluation of crampy abdominal pain and diarrhea. The patient has noticed bright red blood and mucus mixed with stool. Temperature is 38.4 °C (101.3 °F), blood pressure is 103/76 mmHg, pulse is 108/min and respirations are 16/min. Physical examination shows dry mucous membranes. There is mild diffuse abdominal tenderness to palpation. Stool cultures show an immotile Gram-negative organism that produces a toxin capable of inhibiting the 60S ribosomal subunit. Which of the following statements is true regarding the pathogen responsible for this patient’s symptoms?  

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Summary

Shigella is a genus of bacteria known to cause a contagious form of gastroenteritis known as shigellosis. Shigellosis is characterized by an inflammation of the gastrointestinal tract, which causes destruction and inflammation of the epithelium, leading to dysentery with symptoms like severe abdominal and rectal cramping and pain, a fever, and watery diarrhea with mucous with or without blood or pus. Shigella is transmitted through the fecal-to-oral route, mainly through fingers, food, and flies. It's diagnosed with a fecal sample and treatment centers around fluid and electrolyte replenishment and antibiotics.

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