00:00 / 00:00




Cardiovascular system

Vascular disorders

Arterial disease

Angina pectoris

Stable angina

Unstable angina

Myocardial infarction

Prinzmetal angina

Coronary steal syndrome

Peripheral artery disease

Subclavian steal syndrome


Aortic dissection


Behcet's disease

Kawasaki disease


Hypertensive emergency

Renal artery stenosis

Coarctation of the aorta

Cushing syndrome

Conn syndrome


Polycystic kidney disease


Orthostatic hypotension


Familial hypercholesterolemia



Chronic venous insufficiency


Deep vein thrombosis




Vascular tumors

Human herpesvirus 8 (Kaposi sarcoma)


Congenital heart defects

Truncus arteriosus

Transposition of the great vessels

Total anomalous pulmonary venous return

Tetralogy of Fallot

Hypoplastic left heart syndrome

Patent ductus arteriosus

Ventricular septal defect

Coarctation of the aorta

Atrial septal defect

Cardiac arrhythmias

Atrial flutter

Atrial fibrillation

Premature atrial contraction

Atrioventricular nodal reentrant tachycardia (AVNRT)

Wolff-Parkinson-White syndrome

Ventricular tachycardia

Brugada syndrome

Premature ventricular contraction

Long QT syndrome and Torsade de pointes

Ventricular fibrillation

Atrioventricular block

Bundle branch block

Pulseless electrical activity

Valvular disorders

Tricuspid valve disease

Pulmonary valve disease

Mitral valve disease

Aortic valve disease


Dilated cardiomyopathy

Restrictive cardiomyopathy

Hypertrophic cardiomyopathy

Heart failure

Heart failure

Cor pulmonale

Cardiac infections



Rheumatic heart disease

Pericardial disorders

Pericarditis and pericardial effusion

Cardiac tamponade

Dressler syndrome

Cardiac tumors

Cardiac tumors

Cardiovascular system pathology review

Acyanotic congenital heart defects: Pathology review

Cyanotic congenital heart defects: Pathology review

Atherosclerosis and arteriosclerosis: Pathology review

Coronary artery disease: Pathology review

Peripheral artery disease: Pathology review

Valvular heart disease: Pathology review

Cardiomyopathies: Pathology review

Heart failure: Pathology review

Supraventricular arrhythmias: Pathology review

Ventricular arrhythmias: Pathology review

Heart blocks: Pathology review

Aortic dissections and aneurysms: Pathology review

Pericardial disease: Pathology review

Endocarditis: Pathology review

Hypertension: Pathology review

Shock: Pathology review

Vasculitis: Pathology review

Cardiac and vascular tumors: Pathology review

Dyslipidemias: Pathology review




0 / 32 complete

USMLE® Step 1 questions

0 / 8 complete

High Yield Notes

5 pages



of complete


USMLE® Step 1 style questions USMLE

of complete

A 78-year-old male presents to the emergency department with altered mental status and fatigue. He is found to be critically ill and is admitted to the intensive care unit (ICU) for further evaluation and monitoring. While in the ICU, the patient has a Swan-Ganz catheter placed in the right heart for continuous hemodynamic measurements. An initial set of readings is demonstrated below:

Which of the following is the most likely cause of this patient's clinical presentation?

External References

First Aid








Cardiogenic shock

MI p. 311

pulse pressure in p. 292


Content Reviewers

Rishi Desai, MD, MPH


Tanner Marshall, MS

Vincent Waldman, PhD

So, when we talk about ischemia, we’re usually talking about this lack of blood flow to a specific area of tissue. For example, with a heart attack, a coronary artery in the heart that supplies the left ventricle with blood gets blocked, so that localized area of heart tissue doesn’t get enough blood and oxygen; that damage is localized to that left ventricle. Shock is like ischemia, but on a global scale. In other words, it’s a circulatory failure of the whole body; blood flow to tissues is dangerously low, which leads to cellular injury, possibly damages multiple organs, and can even lead to multiple organ failure if not treated immediately.

Okay, so with shock, the body’s tissues aren’t getting enough oxygen via the blood, right? Normally, blood perfuses through tissue and delivers oxygen because there’s enough pressure in the circulatory system to push it through; so, blood pressure majorly affects the amount of blood perfusing through tissues.

Now, blood pressure is determined by two components: the resistance to blood flow in the blood vessels, which is affected by things like vessel length, blood viscosity, and vessel diameter; and the cardiac output, which is the volume of blood pumped by the heart through the body per minute. You can break that down into heart rate, or the number of beats per minute, multiplied by stroke volume, or the amount pumped out each beat. The stroke volume is found by taking the total volume of blood left over after contraction, which is called the end-systolic volume, and subtracting it from the total volume in the heart after filling, or the end-diastolic volume.


Shock refers to a failure in tissue perfusion affecting the whole body, putting tissues and organs at risk for injury and ultimately organ failure. Causes of shock are classified into three main categories with some subcategories.

First, there is hypovolemic shock which happens when dehydration or hemorrhage reduces the volume of blood in the blood vessels. Another category is cardiogenic shock, which happens when a direct injury like a heart attack or an obstruction like a pericardial effusion prevents the heart from pumping blood efficiently. The third category is distributive shock, which occurs when something like an allergic reaction or damage to the nervous system - called neurogenic shock causes the blood vessels to vasodilate and become leaky which reduces the resistance and lowers the blood pressure.

Common symptoms of shock include low blood pressure, tachycardia, cold and clammy skin, confusion and disorientation, and blue or gray skin, especially on the extremities. Shock treatment depends on the underlying cause but typically involves restoring blood flow to the vital organs through measures such as fluid resuscitation, medications, or respiratory support.


Copyright © 2023 Elsevier, except certain content provided by third parties

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.