Thymoma

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Summary of Thymoma

A thymoma is a tumor originating from the epithelial cells of the thymus that may be benign or malignant. A third of all people with a thymoma have symptoms caused by compression of the surrounding organs by an expansive mass. These problems may take the form of superior vena cava syndrome, dysphagia, cough, or chest pain. One-third of patients have their tumors discovered because they have an associated autoimmune disorder. Thymomas are frequently associated with the neuromuscular disorder myasthenia gravis. Additional associated autoimmune conditions include pure red cell aplasia and Good syndrome.

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Thymoma

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Preview

A 52-year-old woman comes to the office because of worsening fatigue for 3 months. She states that at the end of the day, "I just can't keep my arms up, even to comb my hair!" She also refers difficulty keeping her eyes open after prolonged upwards gaze. She denies falls, ataxia, history of stroke, or hemoptysis. Her medical history includes a sore throat two weeks ago. She has a 15 pack-year smoking history. Pulmonary auscultation shows her lungs are clear bilaterally. A chest X-ray is performed and reveals a mass, which is further evaluated with CT. The mass is outlined in the image below. Which of the following is the most likely diagnosis?

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