Tubular reabsorption and secretion of weak acids and bases

Tubular reabsorption and secretion of weak acids and bases are important processes that occur in the kidneys to maintain the balance of electrolytes and pH in the body.

Weak acids and bases are molecules that can exist in charged or uncharged forms depending on the pH of their environment. In the kidneys, these molecules can be filtered out of the blood and enter the tubular fluid of the nephron.

During tubular reabsorption, the uncharged form of weak acids or bases can be reabsorbed by the tubular cells and returned to the bloodstream. Conversely, during tubular secretion, the tubular cells can actively transport the charged form of weak acids or bases from the bloodstream into the tubular fluid.