Renal system anatomy and physiology
Tubular reabsorption and secretion of weak acids and bases
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Weak acids and bases are molecules that can exist in charged or uncharged forms depending on the pH of their environment. In the kidneys, these molecules can be filtered out of the blood and enter the tubular fluid of the nephron.
During tubular reabsorption, the uncharged form of weak acids or bases can be reabsorbed by the tubular cells and returned to the bloodstream. Conversely, during tubular secretion, the tubular cells can actively transport the charged form of weak acids or bases from the bloodstream into the tubular fluid.
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