Urinary tract infection (pediatrics): Clinical sciences

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Questions

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A 6-month-old girl is brought to the emergency department for evaluation of irritability and foul-smelling dark urine for two days. The patient’s parent reports that the patient has been tolerating oral intake without vomiting. The patient has no chronic medical conditions and has never taken antibiotics. Temperature is 38°C (100.4°F), pulse is 167/min, respiratory rate is 40/min, blood pressure is 90/50 mmHg, and oxygen saturation is 99% on room air. On physical examination, the patient is crying but is consolable. Mucous membranes appear moist. Abdominal exam is normal. Cardiopulmonary and HEENT examinations are within normal limits. Genitourinary examination shows normal appearing female genitalia. A straight catheterization is performed with results shown below. Which of the following is the most appropriate antibiotic to initiate at this time?  

Laboratory value  
Result
Urinalysis

Color
Clear
Specific gravity  
1.013  
Glucose
negative
Blood
negative
Leukocyte esterase  
Large
Nitrites
Positive
Leukocytes
50-100/hpf  
Erythrocytes
1-2/hpf  
Dysmorphic RBCs  
Absent
Casts
none

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Urinary tract infection, or UTI for short, is a common bacterial infection in children that can involve any part of the urinary tract. In children, UTIs are usually caused by gastrointestinal flora, such as Escherichia coli, that ascend into the bladder or kidneys, causing cystitis, pyelonephritis, or even urosepsis. If not treated promptly, UTIs can result in long-term complications, such as renal scarring, hypertension, and chronic renal disease. The management of UTIs depends on the patient’s age; more specifically, whether they are less or more than 2 months old.

If a child presents with a chief concern suggesting a UTI, you should first perform an ABCDE assessment to determine whether the child is stable or unstable. If your patient is unstable, stabilize the airway, breathing, and circulation. Next, obtain IV access, administer IV fluids, and start broad-spectrum antibiotics. Finally, begin continuous vital sign monitoring, including blood pressure, heart rate, respiratory rate, and oxygen saturation. If needed, don’t forget to provide supplemental oxygen.

Okay, now let’s go back to the ABCDE assessment and take a look at stable patients. In this case, start by obtaining a focused history and physical exam. Next, assess the patient's age, which will guide the treatment!

First, let’s take a look at term infants of 2 months of age and younger. These patients typically present with vague systemic symptoms, like fever, fussiness, and lethargy. Additionally, caretakers may report poor oral intake or vomiting, and they may describe the baby’s urine as foul-smelling. Next, the physical exam typically reveals an ill-appearing, uncomfortable infant with a body temperature of 38 degrees Celsius or higher. The physical exam could also reveal tachycardia and suprapubic tenderness.

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